Abstract
Background: Cytosolic carboxypeptidases (CCPs) are a subfamily of enzymes that modify tubulin. Results: Zebrafish CCPs exhibit overlapping expression in developing organs. Knockdown of CCP1 and CCP5 results in similar defects including severe hydrocephalus and axial curvature. Conclusion: Loss of deglutamylating enzymes causes developmental defects in zebrafish. Significance: CCP1 and CCP5 play important roles in zebrafish embryonic development.
Original language | English (US) |
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Pages (from-to) | 30454-30462 |
Number of pages | 9 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 42 |
DOIs | |
State | Published - Oct 18 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology