Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development

Peter J. Lyons, Matthew R. Sapio, Lloyd D. Fricker

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Cytosolic carboxypeptidases (CCPs) are a subfamily of enzymes that modify tubulin. Results: Zebrafish CCPs exhibit overlapping expression in developing organs. Knockdown of CCP1 and CCP5 results in similar defects including severe hydrocephalus and axial curvature. Conclusion: Loss of deglutamylating enzymes causes developmental defects in zebrafish. Significance: CCP1 and CCP5 play important roles in zebrafish embryonic development.

Original languageEnglish (US)
Pages (from-to)30454-30462
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - Oct 18 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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