Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry

Zhaoming Wang, Hemang Parikh, Jinping Jia, Timothy Myers, Meredith Yeager, Kevin B. Jacobs, Amy Hutchinson, Laurie Burdett, Arpita Ghosh, Michael J. Thun, Susan M. Gapstur, W. Ryan Diver, Jarmo Virtamo, Demetrius Albanes, Geraldine Cancel-Tassin, Antoine Valeri, Olivier Cussenot, Kenneth Offit, Ed Giovannucci, Jing Ma & 16 others Meir J. Stampfer, J. Michael Gaziano, David J. Hunter, Ana Dutra-Clarke, Tomas Kirchhoff, Michael Alavanja, Laura B. Freeman, Stella Koutros, Robert Hoover, Sonja I. Berndt, Richard B. Hayes, Ilir Agalliu, Robert D. Burk, Sholom Wacholder, Gilles Thomas, Laufey Amundadottir

Research output: Contribution to journalArticle

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Abstract

Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ancestry, we genotyped 34 binary Y chromosome markers in 3,995 prostate cancer cases and 3,815 control subjects drawn from four studies. In this set, we identified nominally significant association between a rare haplogroup, E1b1b1c, and prostate cancer in stage I (P = 0.012, OR = 0.51; 95% confidence interval 0.30-0.87). Population substructure of E1b1b1c carriers suggested Ashkenazi Jewish ancestry, prompting a replication phase in individuals of both European and Ashkenazi Jewish ancestry. The association was not significant for prostate cancer overall in studies of either Ashkenazi Jewish (1,686 cases and 1,597 control subjects) or European (686 cases and 734 control subjects) ancestry (P meta = 0.078), but a meta-analysis of stage I and II studies revealed a nominally significant association with prostate cancer risk (P meta = 0.010, OR = 0.77; 95% confidence interval 0.62-0.94). Comparing haplogroup frequencies between studies, we noted strong similarities between those conducted in the US and France, in which the majority of men carried R1 haplogroups, resembling Northwestern European populations. On the other hand, Finns had a remarkably different haplogroup distribution with a preponderance of N1c and I1 haplogroups. In summary, our results suggest that inherited Y chromosome variation plays a limited role in prostate cancer etiology in European populations but warrant follow-up in additional large and well characterized studies of multiple ethnic backgrounds.

Original languageEnglish (US)
Pages (from-to)1173-1185
Number of pages13
JournalHuman Genetics
Volume131
Issue number7
DOIs
StatePublished - Jul 2012

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Y Chromosome
Prostatic Neoplasms
Population
Confidence Intervals
Genetic Markers
France
Meta-Analysis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Wang, Z., Parikh, H., Jia, J., Myers, T., Yeager, M., Jacobs, K. B., ... Amundadottir, L. (2012). Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry. Human Genetics, 131(7), 1173-1185. https://doi.org/10.1007/s00439-012-1139-5

Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry. / Wang, Zhaoming; Parikh, Hemang; Jia, Jinping; Myers, Timothy; Yeager, Meredith; Jacobs, Kevin B.; Hutchinson, Amy; Burdett, Laurie; Ghosh, Arpita; Thun, Michael J.; Gapstur, Susan M.; Ryan Diver, W.; Virtamo, Jarmo; Albanes, Demetrius; Cancel-Tassin, Geraldine; Valeri, Antoine; Cussenot, Olivier; Offit, Kenneth; Giovannucci, Ed; Ma, Jing; Stampfer, Meir J.; Michael Gaziano, J.; Hunter, David J.; Dutra-Clarke, Ana; Kirchhoff, Tomas; Alavanja, Michael; Freeman, Laura B.; Koutros, Stella; Hoover, Robert; Berndt, Sonja I.; Hayes, Richard B.; Agalliu, Ilir; Burk, Robert D.; Wacholder, Sholom; Thomas, Gilles; Amundadottir, Laufey.

In: Human Genetics, Vol. 131, No. 7, 07.2012, p. 1173-1185.

Research output: Contribution to journalArticle

Wang, Z, Parikh, H, Jia, J, Myers, T, Yeager, M, Jacobs, KB, Hutchinson, A, Burdett, L, Ghosh, A, Thun, MJ, Gapstur, SM, Ryan Diver, W, Virtamo, J, Albanes, D, Cancel-Tassin, G, Valeri, A, Cussenot, O, Offit, K, Giovannucci, E, Ma, J, Stampfer, MJ, Michael Gaziano, J, Hunter, DJ, Dutra-Clarke, A, Kirchhoff, T, Alavanja, M, Freeman, LB, Koutros, S, Hoover, R, Berndt, SI, Hayes, RB, Agalliu, I, Burk, RD, Wacholder, S, Thomas, G & Amundadottir, L 2012, 'Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry', Human Genetics, vol. 131, no. 7, pp. 1173-1185. https://doi.org/10.1007/s00439-012-1139-5
Wang, Zhaoming ; Parikh, Hemang ; Jia, Jinping ; Myers, Timothy ; Yeager, Meredith ; Jacobs, Kevin B. ; Hutchinson, Amy ; Burdett, Laurie ; Ghosh, Arpita ; Thun, Michael J. ; Gapstur, Susan M. ; Ryan Diver, W. ; Virtamo, Jarmo ; Albanes, Demetrius ; Cancel-Tassin, Geraldine ; Valeri, Antoine ; Cussenot, Olivier ; Offit, Kenneth ; Giovannucci, Ed ; Ma, Jing ; Stampfer, Meir J. ; Michael Gaziano, J. ; Hunter, David J. ; Dutra-Clarke, Ana ; Kirchhoff, Tomas ; Alavanja, Michael ; Freeman, Laura B. ; Koutros, Stella ; Hoover, Robert ; Berndt, Sonja I. ; Hayes, Richard B. ; Agalliu, Ilir ; Burk, Robert D. ; Wacholder, Sholom ; Thomas, Gilles ; Amundadottir, Laufey. / Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry. In: Human Genetics. 2012 ; Vol. 131, No. 7. pp. 1173-1185.
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abstract = "Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ancestry, we genotyped 34 binary Y chromosome markers in 3,995 prostate cancer cases and 3,815 control subjects drawn from four studies. In this set, we identified nominally significant association between a rare haplogroup, E1b1b1c, and prostate cancer in stage I (P = 0.012, OR = 0.51; 95{\%} confidence interval 0.30-0.87). Population substructure of E1b1b1c carriers suggested Ashkenazi Jewish ancestry, prompting a replication phase in individuals of both European and Ashkenazi Jewish ancestry. The association was not significant for prostate cancer overall in studies of either Ashkenazi Jewish (1,686 cases and 1,597 control subjects) or European (686 cases and 734 control subjects) ancestry (P meta = 0.078), but a meta-analysis of stage I and II studies revealed a nominally significant association with prostate cancer risk (P meta = 0.010, OR = 0.77; 95{\%} confidence interval 0.62-0.94). Comparing haplogroup frequencies between studies, we noted strong similarities between those conducted in the US and France, in which the majority of men carried R1 haplogroups, resembling Northwestern European populations. On the other hand, Finns had a remarkably different haplogroup distribution with a preponderance of N1c and I1 haplogroups. In summary, our results suggest that inherited Y chromosome variation plays a limited role in prostate cancer etiology in European populations but warrant follow-up in additional large and well characterized studies of multiple ethnic backgrounds.",
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AU - Parikh, Hemang

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AU - Jacobs, Kevin B.

AU - Hutchinson, Amy

AU - Burdett, Laurie

AU - Ghosh, Arpita

AU - Thun, Michael J.

AU - Gapstur, Susan M.

AU - Ryan Diver, W.

AU - Virtamo, Jarmo

AU - Albanes, Demetrius

AU - Cancel-Tassin, Geraldine

AU - Valeri, Antoine

AU - Cussenot, Olivier

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AU - Stampfer, Meir J.

AU - Michael Gaziano, J.

AU - Hunter, David J.

AU - Dutra-Clarke, Ana

AU - Kirchhoff, Tomas

AU - Alavanja, Michael

AU - Freeman, Laura B.

AU - Koutros, Stella

AU - Hoover, Robert

AU - Berndt, Sonja I.

AU - Hayes, Richard B.

AU - Agalliu, Ilir

AU - Burk, Robert D.

AU - Wacholder, Sholom

AU - Thomas, Gilles

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