XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans

Yehuda Salzberg, Carlos A. Díaz-Balzac, Nelson J. Ramirez-Suarez, Matthew Attreed, Eillen Tecle, Muriel Desbois, Zaven Kaprielian, Hannes E. Buelow

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of "menorah"- like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously.

Original languageEnglish (US)
JournalCell
Volume155
Issue number2
DOIs
StatePublished - Oct 10 2013

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Neuronal Plasticity
Caenorhabditis elegans
Dendrites
Cues
Skin
Neural Cell Adhesion Molecule L1
Neural Cell Adhesion Molecules
Dynamic mechanical analysis
Substrates
Leucine
Neurons
Tissue
Morphogenesis
Molecular Biology
Proteins
Growth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Salzberg, Y., Díaz-Balzac, C. A., Ramirez-Suarez, N. J., Attreed, M., Tecle, E., Desbois, M., ... Buelow, H. E. (2013). XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. Cell, 155(2). https://doi.org/10.1016/j.cell.2013.08.058

XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. / Salzberg, Yehuda; Díaz-Balzac, Carlos A.; Ramirez-Suarez, Nelson J.; Attreed, Matthew; Tecle, Eillen; Desbois, Muriel; Kaprielian, Zaven; Buelow, Hannes E.

In: Cell, Vol. 155, No. 2, 10.10.2013.

Research output: Contribution to journalArticle

Salzberg, Y, Díaz-Balzac, CA, Ramirez-Suarez, NJ, Attreed, M, Tecle, E, Desbois, M, Kaprielian, Z & Buelow, HE 2013, 'XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans', Cell, vol. 155, no. 2. https://doi.org/10.1016/j.cell.2013.08.058
Salzberg Y, Díaz-Balzac CA, Ramirez-Suarez NJ, Attreed M, Tecle E, Desbois M et al. XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. Cell. 2013 Oct 10;155(2). https://doi.org/10.1016/j.cell.2013.08.058
Salzberg, Yehuda ; Díaz-Balzac, Carlos A. ; Ramirez-Suarez, Nelson J. ; Attreed, Matthew ; Tecle, Eillen ; Desbois, Muriel ; Kaprielian, Zaven ; Buelow, Hannes E. / XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. In: Cell. 2013 ; Vol. 155, No. 2.
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