TY - JOUR
T1 - XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans
AU - Salzberg, Yehuda
AU - Díaz-Balzac, Carlos A.
AU - Ramirez-Suarez, Nelson J.
AU - Attreed, Matthew
AU - Tecle, Eillen
AU - Desbois, Muriel
AU - Kaprielian, Zaven
AU - Bülow, Hannes E.
N1 - Funding Information:
We thank Kang Shen (Stanford University) for communicating results prior to publication; N. Baker, S. Emmons, A. Meléndez, R. Townley, and members of the Bülow laboratory for discussions and comments on the manuscript; Ji Sze, O. Hobert, and J. Culotti for DNA clones; the Caenorhabditis Genetics Center, L. Chen, and S. Mitani for strains; C. Rubin for the α-mCherry antibody; M. Akabas for the use of his cell culture facility; B. Calder and A. Fiser for advice on bioinformatic analyses; M. Lázaro-Peña for injections; S. Bhatt and B. Gonzalez for constructing strains; and C. Crocker for artwork. This work was funded in part by the NIH (T32GM007288 and F31HD066967 to C.A.D.-B., T32GM007491 and F31 NS076243 to M.A., T32GM07491 to E.T., 5R01HD055380 and R21NS081505 to H.E.B., and P30HD071593 and P30CA013330 to Albert Einstein College of Medicine). N.R. is the recipient of a Fulbright fellowship. H.E.B. is an Alfred P. Sloan fellow.
PY - 2013/10/10
Y1 - 2013/10/10
N2 - Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of "menorah"- like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously.
AB - Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of "menorah"- like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously.
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U2 - 10.1016/j.cell.2013.08.058
DO - 10.1016/j.cell.2013.08.058
M3 - Article
C2 - 24120132
AN - SCOPUS:84885673994
SN - 0092-8674
VL - 155
SP - 308
JO - Cell
JF - Cell
IS - 2
ER -