XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans

Yehuda Salzberg, Carlos A. Díaz-Balzac, Nelson J. Ramirez-Suarez, Matthew Attreed, Eillen Tecle, Muriel Desbois, Zaven Kaprielian, Hannes E. Bülow

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Abstract

Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of "menorah"- like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously.

Original languageEnglish (US)
Number of pages1
JournalCell
Volume155
Issue number2
DOIs
StatePublished - Oct 10 2013

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Salzberg, Y., Díaz-Balzac, C. A., Ramirez-Suarez, N. J., Attreed, M., Tecle, E., Desbois, M., Kaprielian, Z., & Bülow, H. E. (2013). XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. Cell, 155(2). https://doi.org/10.1016/j.cell.2013.08.058