XRhythmic modulation of the hematopoietic niche through neutrophil clearance

María Casanova-Acebes, Christophe Pitaval, Linnea A. Weiss, César Nombela-Arrieta, Raphaël Chèvre, Noelia A-González, Yuya Kunisaki, Dachuan Zhang, Nico Van Rooijen, Leslie E. Silberstein, Christian Weber, Takashi Nagasawa, Paul S. Frenette, Antonio Castrillo, Andrés Hidalgo

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the homeostatic clearance of neutrophils provides cues that modulate the physiology of the bone marrow. We identify a population of CD62L LO CXCR4HI neutrophils that have "aged" in the circulation and are eliminated at the end of the resting period in mice. Aged neutrophils infiltrate the bone marrow and promote reductions in the size and function of the hematopoietic niche. Modulation of the niche depends on macrophages and activation of cholesterol-sensing nuclear receptors and is essential for the rhythmic egress of hematopoietic progenitors into the circulation. Our results unveil a process that synchronizes immune and hematopoietic rhythms and expand the ascribed functions of neutrophils beyond inflammation. PaperFlick

Original languageEnglish (US)
JournalCell
Volume153
Issue number5
DOIs
StatePublished - May 23 2013

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Bone
Neutrophils
Modulation
Macrophages
Bone Marrow
Physiology
Cytoplasmic and Nuclear Receptors
Chemical activation
Cholesterol
Macrophage Activation
Cues
Leukocytes
Inflammation
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Casanova-Acebes, M., Pitaval, C., Weiss, L. A., Nombela-Arrieta, C., Chèvre, R., A-González, N., ... Hidalgo, A. (2013). XRhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell, 153(5). https://doi.org/10.1016/j.cell.2013.04.040

XRhythmic modulation of the hematopoietic niche through neutrophil clearance. / Casanova-Acebes, María; Pitaval, Christophe; Weiss, Linnea A.; Nombela-Arrieta, César; Chèvre, Raphaël; A-González, Noelia; Kunisaki, Yuya; Zhang, Dachuan; Van Rooijen, Nico; Silberstein, Leslie E.; Weber, Christian; Nagasawa, Takashi; Frenette, Paul S.; Castrillo, Antonio; Hidalgo, Andrés.

In: Cell, Vol. 153, No. 5, 23.05.2013.

Research output: Contribution to journalArticle

Casanova-Acebes, M, Pitaval, C, Weiss, LA, Nombela-Arrieta, C, Chèvre, R, A-González, N, Kunisaki, Y, Zhang, D, Van Rooijen, N, Silberstein, LE, Weber, C, Nagasawa, T, Frenette, PS, Castrillo, A & Hidalgo, A 2013, 'XRhythmic modulation of the hematopoietic niche through neutrophil clearance', Cell, vol. 153, no. 5. https://doi.org/10.1016/j.cell.2013.04.040
Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N et al. XRhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell. 2013 May 23;153(5). https://doi.org/10.1016/j.cell.2013.04.040
Casanova-Acebes, María ; Pitaval, Christophe ; Weiss, Linnea A. ; Nombela-Arrieta, César ; Chèvre, Raphaël ; A-González, Noelia ; Kunisaki, Yuya ; Zhang, Dachuan ; Van Rooijen, Nico ; Silberstein, Leslie E. ; Weber, Christian ; Nagasawa, Takashi ; Frenette, Paul S. ; Castrillo, Antonio ; Hidalgo, Andrés. / XRhythmic modulation of the hematopoietic niche through neutrophil clearance. In: Cell. 2013 ; Vol. 153, No. 5.
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