Xenotransplantation rejection is antibody-mediated in both sensitized and nonsensitized recipients

Ignazio Roberto Marino, Susanna Celli, Marco Catena, Stefano Gatti, Giorgio Zetti, Gianfranco Ferla, Howard R. Doyle, Nicola Maggiano, Piero Musiani

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

This study analyzes the mechanisms involved in xenotransplantation rejection between closely related species. Hamster hearts were transplanted heterotopically into both normal rats and rats previously sensitized by the transfusion of donor blood. Sequential ultrastructural and immunohistochemical analyses were performed on the grafts, spleens, and sera. The data obtained support the view that induced antibodies directed against the xenograft endothelium play a very important role in producing graft damage. Moreover, the demonstration of antibodies against myocyte determinants suggests that it is possible, in this particular model, that the antiendothelial antibodies are not the only ones involved in the injury process.

Original languageEnglish (US)
Pages (from-to)111-122
Number of pages12
JournalJournal of Investigative Surgery
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Keywords

  • Hamster-to-rat transplant
  • Heart xenotransplantation
  • Xenotransplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Marino, I. R., Celli, S., Catena, M., Gatti, S., Zetti, G., Ferla, G., Doyle, H. R., Maggiano, N., & Musiani, P. (1994). Xenotransplantation rejection is antibody-mediated in both sensitized and nonsensitized recipients. Journal of Investigative Surgery, 7(2), 111-122. https://doi.org/10.3109/08941939409015355