WNK Kinases in Development and Disease

A. R. Rodan, Andreas Jenny

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

WNK (With-No-Lysine (K)) kinases are serine-threonine kinases characterized by an atypical placement of a catalytic lysine within the kinase domain. Mutations in human WNK1 or WNK4 cause an autosomal dominant syndrome of hypertension and hyperkalemia, reflecting the fact that WNK kinases are critical regulators of renal ion transport processes. Here, the role of WNKs in the regulation of ion transport processes in vertebrate and invertebrate renal function, cellular and organismal osmoregulation, and cell migration and cerebral edema will be reviewed, along with emerging literature demonstrating roles for WNKs in cardiovascular and neural development, Wnt signaling, and cancer. Conserved roles for these kinases across phyla are emphasized.

Original languageEnglish (US)
JournalCurrent Topics in Developmental Biology
DOIs
StateAccepted/In press - 2016

Fingerprint

Phosphotransferases
Ion Transport
Lysine
Kidney
Osmoregulation
Hyperkalemia
Protein-Serine-Threonine Kinases
Brain Edema
Invertebrates
Cell Movement
Vertebrates
Hypertension
Mutation
Neoplasms

Keywords

  • Blood pressure
  • C. elegans
  • Drosophila
  • Excretory canal
  • Kidney
  • Lhx8
  • Malpighian tubule
  • Mo25/Cab39
  • SPAK/OSR1
  • Wnt signaling
  • Zebrafish

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

WNK Kinases in Development and Disease. / Rodan, A. R.; Jenny, Andreas.

In: Current Topics in Developmental Biology, 2016.

Research output: Contribution to journalArticle

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