Why Gilgamesh failed: the mechanistic basis of the limits to human lifespan

Brandon Milholland, Jan Vijg

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this Perspective is to clarify for an interdisciplinary audience the fundamental concepts of human longevity and provide evidence for a limit to human lifespan. This observed limit is placed into a broader framework by showing how it has arisen through the process of evolution and by enumerating the molecular mechanisms that may enforce it. Finally, we look toward potential future developments and the prospects for possibly circumventing the current limit.

Original languageEnglish (US)
Pages (from-to)878-884
Number of pages7
JournalNature Aging
Volume2
Issue number10
DOIs
StatePublished - Oct 2022

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Neuroscience (miscellaneous)

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