Whole-animal connectomes of both Caenorhabditis elegans sexes

Steven J. Cook, Travis A. Jarrell, Christopher A. Brittin, Yi Wang, Adam E. Bloniarz, Maksim A. Yakovlev, Ken C.Q. Nguyen, Leo T.H. Tang, Emily A. Bayer, Janet S. Duerr, Hannes E. Buelow, Oliver Hobert, David H. Hall, Scott W. Emmons

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Knowledge of connectivity in the nervous system is essential to understanding its function. Here we describe connectomes for both adult sexes of the nematode Caenorhabditis elegans, an important model organism for neuroscience research. We present quantitative connectivity matrices that encompass all connections from sensory input to end-organ output across the entire animal, information that is necessary to model behaviour. Serial electron microscopy reconstructions that are based on the analysis of both new and previously published electron micrographs update previous results and include data on the male head. The nervous system differs between sexes at multiple levels. Several sex-shared neurons that function in circuits for sexual behaviour are sexually dimorphic in structure and connectivity. Inputs from sex-specific circuitry to central circuitry reveal points at which sexual and non-sexual pathways converge. In sex-shared central pathways, a substantial number of connections differ in strength between the sexes. Quantitative connectomes that include all connections serve as the basis for understanding how complex, adaptive behavior is generated.

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
JournalNature
Volume571
Issue number7763
DOIs
StatePublished - Jul 4 2019

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Caenorhabditis elegans
gender
animals
nervous system
neurophysiology
sexual behavior
electron microscopy
neurons
electrons
Nematoda
organisms

ASJC Scopus subject areas

  • General

Cite this

Cook, S. J., Jarrell, T. A., Brittin, C. A., Wang, Y., Bloniarz, A. E., Yakovlev, M. A., ... Emmons, S. W. (2019). Whole-animal connectomes of both Caenorhabditis elegans sexes. Nature, 571(7763), 63-71. https://doi.org/10.1038/s41586-019-1352-7

Whole-animal connectomes of both Caenorhabditis elegans sexes. / Cook, Steven J.; Jarrell, Travis A.; Brittin, Christopher A.; Wang, Yi; Bloniarz, Adam E.; Yakovlev, Maksim A.; Nguyen, Ken C.Q.; Tang, Leo T.H.; Bayer, Emily A.; Duerr, Janet S.; Buelow, Hannes E.; Hobert, Oliver; Hall, David H.; Emmons, Scott W.

In: Nature, Vol. 571, No. 7763, 04.07.2019, p. 63-71.

Research output: Contribution to journalArticle

Cook, SJ, Jarrell, TA, Brittin, CA, Wang, Y, Bloniarz, AE, Yakovlev, MA, Nguyen, KCQ, Tang, LTH, Bayer, EA, Duerr, JS, Buelow, HE, Hobert, O, Hall, DH & Emmons, SW 2019, 'Whole-animal connectomes of both Caenorhabditis elegans sexes', Nature, vol. 571, no. 7763, pp. 63-71. https://doi.org/10.1038/s41586-019-1352-7
Cook SJ, Jarrell TA, Brittin CA, Wang Y, Bloniarz AE, Yakovlev MA et al. Whole-animal connectomes of both Caenorhabditis elegans sexes. Nature. 2019 Jul 4;571(7763):63-71. https://doi.org/10.1038/s41586-019-1352-7
Cook, Steven J. ; Jarrell, Travis A. ; Brittin, Christopher A. ; Wang, Yi ; Bloniarz, Adam E. ; Yakovlev, Maksim A. ; Nguyen, Ken C.Q. ; Tang, Leo T.H. ; Bayer, Emily A. ; Duerr, Janet S. ; Buelow, Hannes E. ; Hobert, Oliver ; Hall, David H. ; Emmons, Scott W. / Whole-animal connectomes of both Caenorhabditis elegans sexes. In: Nature. 2019 ; Vol. 571, No. 7763. pp. 63-71.
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