What we know about facilitative glucose transporters: Lessons from cultured cells, animal models, and human studies

Naira Gorovits, Maureen J. Charron

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Glucose uptake by all cells in the organism by glucose transport proteins is among the most essential processes in life. The process of glucose uptake into tissues is performed by glucose transporters. This review focuses on the biology of facilitative glucose transporters (GLUTs). The knowledge that has accumulated for more than a decade with respect to the regulation of GLUT expression and function in various experimental conditions points to the great potential for GLUTs to be utilized as targets for designing therapies for treatment of diseases related to impaired regulation of glucose homeostasis including type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)163-172
Number of pages10
JournalBiochemistry and Molecular Biology Education
Volume31
Issue number3
DOIs
StatePublished - May 2003

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Facilitative Glucose Transport Proteins
Cultured Cells
Animals
Animal Models
Cells
Glucose
Medical problems
Type 2 Diabetes Mellitus
Homeostasis
Tissue

Keywords

  • Diabetes
  • Glucose uptake
  • GLUT
  • Insulin action

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

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