Voltage-gated potassium channel antibody-mediated syndromes: A spectrum of clinical manifestations

Laura Rueff, Jerome J. Graber, Melissa Bernbaum, Ruben I. Kuzniecky

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Immune-related neurologic disorders have long been recognized. A number of specific targets have been identified, including neurons, Purkinje cells, and pre- and postsynaptic receptors. Over the past decade, antibodies against voltage-gated potassium channels (VGKCs) have been reported in a number of neurologic syndromes, such as neuromyotonia, limbic encephalitis, and Morvan's syndrome. Recent advances have supported the pathologic mechanism of VGKC in these disorders, their response to therapy, and the possible mechanisms of peripheral, central, and autonomic dysfunctions seen in these disorders. We present a patient with 1 of these syndromes and review the literature of these disorders.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalReviews in Neurological Diseases
Volume5
Issue number2
StatePublished - Mar 1 2008

Keywords

  • Limbic encephalitis
  • Morvan's syndrome
  • Neuromyotonia
  • Voltage-gated potassium channel

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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