TY - JOUR
T1 - Voltage-gated potassium channel antibody-mediated syndromes
T2 - A spectrum of clinical manifestations
AU - Rueff, Laura
AU - Graber, Jerome J.
AU - Bernbaum, Melissa
AU - Kuzniecky, Ruben I.
PY - 2008/3
Y1 - 2008/3
N2 - Immune-related neurologic disorders have long been recognized. A number of specific targets have been identified, including neurons, Purkinje cells, and pre- and postsynaptic receptors. Over the past decade, antibodies against voltage-gated potassium channels (VGKCs) have been reported in a number of neurologic syndromes, such as neuromyotonia, limbic encephalitis, and Morvan's syndrome. Recent advances have supported the pathologic mechanism of VGKC in these disorders, their response to therapy, and the possible mechanisms of peripheral, central, and autonomic dysfunctions seen in these disorders. We present a patient with 1 of these syndromes and review the literature of these disorders.
AB - Immune-related neurologic disorders have long been recognized. A number of specific targets have been identified, including neurons, Purkinje cells, and pre- and postsynaptic receptors. Over the past decade, antibodies against voltage-gated potassium channels (VGKCs) have been reported in a number of neurologic syndromes, such as neuromyotonia, limbic encephalitis, and Morvan's syndrome. Recent advances have supported the pathologic mechanism of VGKC in these disorders, their response to therapy, and the possible mechanisms of peripheral, central, and autonomic dysfunctions seen in these disorders. We present a patient with 1 of these syndromes and review the literature of these disorders.
KW - Limbic encephalitis
KW - Morvan's syndrome
KW - Neuromyotonia
KW - Voltage-gated potassium channel
UR - http://www.scopus.com/inward/record.url?scp=46749098616&partnerID=8YFLogxK
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M3 - Review article
C2 - 18660738
AN - SCOPUS:46749098616
VL - 5
SP - 65
EP - 72
JO - Reviews in Neurological Diseases
JF - Reviews in Neurological Diseases
SN - 1545-2913
IS - 2
ER -