Vitamin D and kidney disease

what we know and what we do not know

Antonio J ose Inda Filho, Michal L. Melamed

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Vitamin D deficiency is common in the chronic kidney disease (CKD) population. CKD has been recognized as a significant public health problem and CKD patients are at increased risk of total and cardiovascular morbidity and mortality. There are increasing epidemiological data suggesting that vitamin D deficiency may play a role in overall morbidity and mortality associated with CKD. The vitamin D hormonal system is classically implicated in the regulation of calcium homeostasis and bone metabolism but there is ample evidence to support the claim that extra renal conversion of 25(OH)D to 1.25(OH)2 has significant biological roles beyond those traditionally ascribed to vitamin D. Based on the current state of evidence this review intends to give an update on novel biological and clinical insights with relevance to the steroid hormone vitamin D specifically in patients with kidney disease.

Original languageEnglish (US)
Pages (from-to)323-331
Number of pages9
JournalJornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Volume35
Issue number4
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

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Kidney Diseases
Chronic Renal Insufficiency
Vitamin D
Vitamin D Deficiency
Morbidity
Mortality
Homeostasis
Public Health
Steroids
Hormones
Calcium
Kidney
Bone and Bones
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Vitamin D deficiency is common in the chronic kidney disease (CKD) population. CKD has been recognized as a significant public health problem and CKD patients are at increased risk of total and cardiovascular morbidity and mortality. There are increasing epidemiological data suggesting that vitamin D deficiency may play a role in overall morbidity and mortality associated with CKD. The vitamin D hormonal system is classically implicated in the regulation of calcium homeostasis and bone metabolism but there is ample evidence to support the claim that extra renal conversion of 25(OH)D to 1.25(OH)2 has significant biological roles beyond those traditionally ascribed to vitamin D. Based on the current state of evidence this review intends to give an update on novel biological and clinical insights with relevance to the steroid hormone vitamin D specifically in patients with kidney disease.",
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