Vitamin D and insulin resistance in non-diabetic women's interagency HIV study participants

Oluwatoyin M. Adeyemi, Britt Livak, Jennifer Orsi, Marshall J. Glesby, Maria C. Villacres, Kathleen M. Weber, Anjali Sharma, Elizabeth Golub, Mary Young, Mardge Cohen, Phyllis C. Tien

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We explored the relationship between vitamin D levels and insulin resistance (IR) among 1082 nondiabetic (754 HIV-infected) women enrolled in the Women's Interagency HIV study (WIHS), a large and well-established cohort of HIV infected and uninfected women in the US. Vitamin D levels 20-29 ng/mL were considered insufficient and <20 ng/mL deficient. IR was estimated using the homeostasis model assessment (HOMA) and a clinically significant cut-off ≥2.6 was used for HOMA-IR. In the unadjusted analysis, women who were vitamin D insufficient or deficient were 1.62 (95% CI: 1.01-2.61, p=0.05) and 1.70 (95% CI: 1.11-2.60, p=0.02) times more likely to have HOMA values≥2.6 compared to women with sufficient vitamin D. The association did not remain significant after adjustment for factors associated with IR. Among the 754 HIV-infected women, current PI use (OR 1.61, 95% CI: 1.13-2.28, p=0.008) remained independently associated with HOMA ≥2.6 while vitamin D insufficiency (OR 1.80, 95% CI: 0.99-3.27, p=0.05) was marginally associated with HOMA ≥2.6 after adjustment. Ethnicity, body mass index, smoking status, and hepatitis C status were independently associated with insulin resistance in HIV-infected and uninfected women. We found a marginally significant association between vitamin D insufficiency and insulin resistance among nondiabetic HIV-infected WIHS women.

Original languageEnglish (US)
Pages (from-to)320-325
Number of pages6
JournalAIDS Patient Care and STDs
Volume27
Issue number6
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Vitamin D and insulin resistance in non-diabetic women's interagency HIV study participants'. Together they form a unique fingerprint.

  • Cite this

    Adeyemi, O. M., Livak, B., Orsi, J., Glesby, M. J., Villacres, M. C., Weber, K. M., Sharma, A., Golub, E., Young, M., Cohen, M., & Tien, P. C. (2013). Vitamin D and insulin resistance in non-diabetic women's interagency HIV study participants. AIDS Patient Care and STDs, 27(6), 320-325. https://doi.org/10.1089/apc.2012.0400