Ventral intermediate thalamic stimulation for monoclonal gammopathy-associated tremor: Case report

Donald C. Shields, Alice W. Flaherty, Emad N. Eskandar, Ziv M. Williams

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND AND IMPORTANCE: Peripheral and central sensory loss are often associated with significant tremor or sensory ataxia, which can be highly refractory to medical therapy. CLINICAL PRESENTATION: We present the case of a 67-year-old man with progressive and debilitating intention tremor from monoclonal gammopathy-associated peripheral neuropathy. The patient was implanted with bilateral thalamic deep brain stimulator electrodes under microelectrode guidance. Following optimization of stimulation parameters, the patient's appendicular tremor and gait improved, as did his general activities of daily living. CONCLUSION: These initial findings suggest that deep brain stimulation may benefit not only tremor presumed to originate from central nervous system dysfunction, but also tremor originating peripherally from neuropathy-related sensory loss.

Original languageEnglish (US)
JournalNeurosurgery
Volume68
Issue number5
DOIs
StatePublished - May 1 2011
Externally publishedYes

Fingerprint

Paraproteinemias
Tremor
Deep Brain Stimulation
Microelectrodes
Peripheral Nervous System Diseases
Ataxia
Activities of Daily Living
Gait
Electrodes
Central Nervous System
Brain

Keywords

  • Action tremor
  • Deep brain stimulation
  • Microelectrode recording
  • Monoclonal gammopathy
  • Polyneuropathy
  • Thalamus

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Ventral intermediate thalamic stimulation for monoclonal gammopathy-associated tremor : Case report. / Shields, Donald C.; Flaherty, Alice W.; Eskandar, Emad N.; Williams, Ziv M.

In: Neurosurgery, Vol. 68, No. 5, 01.05.2011.

Research output: Contribution to journalArticle

Shields, Donald C. ; Flaherty, Alice W. ; Eskandar, Emad N. ; Williams, Ziv M. / Ventral intermediate thalamic stimulation for monoclonal gammopathy-associated tremor : Case report. In: Neurosurgery. 2011 ; Vol. 68, No. 5.
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