TY - JOUR
T1 - Ventilatory response to consecutive short hypercapnic challenges in children with obstructive sleep apnea
AU - Gozal, D.
AU - Arens, R.
AU - Omlin, K. J.
AU - Ben-Ari, J. H.
AU - Aljadeff, G.
AU - Harper, R. M.
AU - Keens, T. G.
N1 - Funding Information:
Supported by the International Foundation for Science (IFS) by a Grant to Hilaire Macaire Womeni.
PY - 1995
Y1 - 1995
N2 - In healthy adults, a ventilatory pattern characterized by progressively increased tidal volume (VT), and decreased respiratory rate (RR) accompany repeated short hypercapnic ventilatory challenges, while minute ventilation (V̇E) remains constant. We hypothesized that the peculiar ventilatory pattern seen in adults would be blunted in children with obstructive sleep apnea syndrome (OSAS) who undergo comparable intermittent or chronic alveolar PCO2 elevation. We measured ventilatory responses to five challenges of 2- min duration (CL-C5) with 5% CO2 in O2, separated by 5-min room-air breathing intervals (R1-R4), in nine children with OSAS and in eight age-, sex-, and body mass index-matched controls. In all children, CO2 significantly increased V̇E when compared with baseline conditions (22.3 ± 2.2 vs. 9.5 ± 0.9 (SE) l/min; P < 0.001). In control subjects, progressive VT increases from 0.67 ± 0.10 liter in C1 to 0.92 ± 0.13 liter in C5 occurred (P < 0.01), whereas RR decreased from 33.9 ± 5.1 breaths/min in C1 to 27.8 ± 3.7 breaths/min in C5 (P < 0.02), resulting in V̇E increases across CO2 challenges (22.3 ± 4.9 l/min in C1 vs. 25.1 ± 5.0 l/min in C5; P < 0.005). The RR decrease was primarily related to progressive prolongation of expiratory time (TE) (1.1 ± 0.1 s in C1 to 1.5 ± 0.2 s in C5; P < 0.002). In contrast, VT, RR, and TE did not change in a consistent fashion in OSAS patients with repeated CO2 challenges (OSAS vs. control: P < 0.0001). Furthermore, in OSAS, V̇E was similar with repeated challenges (22.4 ± 2.2 l/min in C1 vs. 23.9 ± 1.91/min; P = not significant), such that changes in V̇E over time significantly differed in OSAS and controls (P < 0.001). We conclude that healthy children modify their ventilatory strategy to repeated hypercapnia. We speculate that in OSAS these mechanisms are already fully implemented because of recurrent alveolar hypoventilation accompanying increased upper airway resistance, leading to blunted temporal trends of ventilatory response.
AB - In healthy adults, a ventilatory pattern characterized by progressively increased tidal volume (VT), and decreased respiratory rate (RR) accompany repeated short hypercapnic ventilatory challenges, while minute ventilation (V̇E) remains constant. We hypothesized that the peculiar ventilatory pattern seen in adults would be blunted in children with obstructive sleep apnea syndrome (OSAS) who undergo comparable intermittent or chronic alveolar PCO2 elevation. We measured ventilatory responses to five challenges of 2- min duration (CL-C5) with 5% CO2 in O2, separated by 5-min room-air breathing intervals (R1-R4), in nine children with OSAS and in eight age-, sex-, and body mass index-matched controls. In all children, CO2 significantly increased V̇E when compared with baseline conditions (22.3 ± 2.2 vs. 9.5 ± 0.9 (SE) l/min; P < 0.001). In control subjects, progressive VT increases from 0.67 ± 0.10 liter in C1 to 0.92 ± 0.13 liter in C5 occurred (P < 0.01), whereas RR decreased from 33.9 ± 5.1 breaths/min in C1 to 27.8 ± 3.7 breaths/min in C5 (P < 0.02), resulting in V̇E increases across CO2 challenges (22.3 ± 4.9 l/min in C1 vs. 25.1 ± 5.0 l/min in C5; P < 0.005). The RR decrease was primarily related to progressive prolongation of expiratory time (TE) (1.1 ± 0.1 s in C1 to 1.5 ± 0.2 s in C5; P < 0.002). In contrast, VT, RR, and TE did not change in a consistent fashion in OSAS patients with repeated CO2 challenges (OSAS vs. control: P < 0.0001). Furthermore, in OSAS, V̇E was similar with repeated challenges (22.4 ± 2.2 l/min in C1 vs. 23.9 ± 1.91/min; P = not significant), such that changes in V̇E over time significantly differed in OSAS and controls (P < 0.001). We conclude that healthy children modify their ventilatory strategy to repeated hypercapnia. We speculate that in OSAS these mechanisms are already fully implemented because of recurrent alveolar hypoventilation accompanying increased upper airway resistance, leading to blunted temporal trends of ventilatory response.
KW - carbon dioxide
KW - chemoreceptor
KW - respiratory control
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U2 - 10.1152/jappl.1995.79.5.1608
DO - 10.1152/jappl.1995.79.5.1608
M3 - Article
C2 - 8594021
AN - SCOPUS:0028822170
SN - 8750-7587
VL - 79
SP - 1608
EP - 1614
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 5
ER -