Vaping-Associated Acute Respiratory Failure Due to Acute Lipoid Pneumonia

Peter V. Dicpinigaitis, Polina Trachuk, Feizal Fakier, Mestawet Teka, Mark J. Suhrland

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Electronic cigarettes, pens, cartridges and other devices were developed as nicotine delivery systems not requiring combustion of tobacco leaves. This technology was subsequently employed to deliver the cannabis component tetrahydrocannabinol (THC) via products often manufactured without adequate quality oversight and sold illegally. Recently, five patients presenting within a 2-month period with acute respiratory failure due to acute lipoid pneumonia after inhaling THC-containing concentrates or oils have been described. We report a 28-year-old previously healthy man who presented in acute respiratory failure 2 weeks after initiating use of a street-purchased THC-containing vape cartridge. Bronchoalveolar lavage cytology with oil red O staining confirmed the diagnosis of acute lipoid pneumonia. Diffuse alveolar hemorrhage and eosinophilic pneumonia were excluded. Evolving evidence supports a clinical entity of acute respiratory failure due to acute, exogenous lipoid pneumonia induced by THC-containing concentrates or oils inhaled through a variety of vaping products. All six patients reported to date received intravenous corticosteroids and survived to hospital discharge.

Original languageEnglish (US)
JournalLung
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Dronabinol
Respiratory Insufficiency
Pneumonia
Oils
Pulmonary Eosinophilia
Bronchoalveolar Lavage
Cannabis
Nicotine
Inhalation
Tobacco
Cell Biology
Adrenal Cortex Hormones
Staining and Labeling
Hemorrhage
Technology
Equipment and Supplies
Vaping

Keywords

  • Acute respiratory failure
  • Electronic cigarette
  • Lipoid pneumonia
  • Nicotine
  • Tetrahydrocannabinol (THC)
  • Vaping

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Vaping-Associated Acute Respiratory Failure Due to Acute Lipoid Pneumonia. / Dicpinigaitis, Peter V.; Trachuk, Polina; Fakier, Feizal; Teka, Mestawet; Suhrland, Mark J.

In: Lung, 01.01.2019.

Research output: Contribution to journalArticle

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