Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease: a case report and review of the literature

Amit A. Raheja, Yvonne W. Lui, Alberto Pinzon-Ardila, Ruth P. Lim, Steven A. Sparr

Research output: Contribution to journalArticle

8 Scopus citations


A case of Whipple's disease with development of antibiotic resistance is reported. The patient's symptomatology correlated with evolution of diffusion abnormality rather than with lesion enhancement. The lesion demonstrated no hyperperfusion, moderately elevated choline, and decreased N-acetylaspartate. Conventional magnetic resonance (MR) imaging findings of central nervous system Whipple's disease are nonspecific and may mimic neoplasm. MR perfusion and spectroscopy findings are reported, which may assist in diagnosis. Change in diffusion restriction appears to be a potential imaging indicator of clinical progression and response to therapy.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalClinical Imaging
Issue number2
Publication statusPublished - Mar 1 2010



  • Central nervous system
  • Diffusion
  • Infection
  • Magnetic resonance imaging
  • Whipple's disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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