Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease: a case report and review of the literature

Amit A. Raheja, Yvonne W. Lui, Alberto Pinzon-Ardila, Ruth P. Lim, Steven A. Sparr

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A case of Whipple's disease with development of antibiotic resistance is reported. The patient's symptomatology correlated with evolution of diffusion abnormality rather than with lesion enhancement. The lesion demonstrated no hyperperfusion, moderately elevated choline, and decreased N-acetylaspartate. Conventional magnetic resonance (MR) imaging findings of central nervous system Whipple's disease are nonspecific and may mimic neoplasm. MR perfusion and spectroscopy findings are reported, which may assist in diagnosis. Change in diffusion restriction appears to be a potential imaging indicator of clinical progression and response to therapy.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalClinical Imaging
Volume34
Issue number2
DOIs
StatePublished - Mar 2010

Fingerprint

Whipple Disease
Central Nervous System Diseases
Microbial Drug Resistance
Choline
Magnetic Resonance Spectroscopy
Perfusion
Magnetic Resonance Imaging
Neoplasms
Therapeutics
N-acetylaspartate

Keywords

  • Central nervous system
  • Diffusion
  • Infection
  • Magnetic resonance imaging
  • Whipple's disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease : a case report and review of the literature. / Raheja, Amit A.; Lui, Yvonne W.; Pinzon-Ardila, Alberto; Lim, Ruth P.; Sparr, Steven A.

In: Clinical Imaging, Vol. 34, No. 2, 03.2010, p. 143-147.

Research output: Contribution to journalArticle

Raheja, Amit A. ; Lui, Yvonne W. ; Pinzon-Ardila, Alberto ; Lim, Ruth P. ; Sparr, Steven A. / Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease : a case report and review of the literature. In: Clinical Imaging. 2010 ; Vol. 34, No. 2. pp. 143-147.
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