TY - JOUR
T1 - Urinary TWEAK and the activity of lupus nephritis
AU - Schwartz, Noa
AU - Su, Lihe
AU - Burkly, Linda C.
AU - Mackay, Meggan
AU - Aranow, Cynthia
AU - Kollaros, Maria
AU - Michaelson, Jennifer S.
AU - Rovin, Brad
AU - Putterman, Chaim
N1 - Funding Information:
We thank Huijuan Song from Ohio State University College of Medicine and Public Health, Columbus, OH, for assistance with the OSS sample cohort. This study was supported by Biogen Idec (C.P.), and NIH grants AR48692 and AI51392 (to C.P.), and DK55546 (to B.R.). N.S. was supported by the Medical Student Research Preceptorship Award from the American College of Rheumatology Research and Education Foundation, a grant from the New York Chapter of the Arthritis Foundation, and the Gina Finzi Memorial Student Summer Fellowship from the Lupus Foundation of America.
PY - 2006/12
Y1 - 2006/12
N2 - The TNF superfamily cytokine TWEAK induces mesangial cells, podocytes, and endothelial cells to secrete pro-inflammatory chemokines including MCP-1, IP-10 and RANTES, which are crucial in the pathogenesis of lupus nephritis (LN). As TWEAK regulates the secretion of these inflammatory mediators, we studied whether urinary TWEAK (uTWEAK) levels might be predictive and/or diagnostic in LN. In a cross-sectional study of a large, multi-center cohort of systemic lupus erythematosus (SLE) patients, uTWEAK levels were higher in patients with active as compared to never or non-active nephritis (median (IQR): 16.3 (9.9-23.0) versus 5.5 (2.3-16.8) pg/mg creatinine, p = 0.001), and levels of uTWEAK correlated with the renal SLE disease activity index (rSLEDAI) score (r = 0.405, p < 0.001). uTWEAK levels were higher in patients undergoing a flare as compared to patients with chronic stable disease (11.1 (8.1-18.2) and 5.2 (2.3-15.3) pg/mg creatinine, respectively; p = 0.036). Moreover, uTWEAK levels were significantly higher in patients undergoing a renal flare, as opposed to a non-renal flare (12.4 (9.1-18.2) and 5.2 (3.0-11.9) pg/mg creatinine, respectively; p = 0.029). An accurate, non-invasive method to repeatedly assess kidney disease in lupus would be very helpful in managing these often challenging patients. Our study indicates that urinary TWEAK levels may be useful as a novel biomarker in LN.
AB - The TNF superfamily cytokine TWEAK induces mesangial cells, podocytes, and endothelial cells to secrete pro-inflammatory chemokines including MCP-1, IP-10 and RANTES, which are crucial in the pathogenesis of lupus nephritis (LN). As TWEAK regulates the secretion of these inflammatory mediators, we studied whether urinary TWEAK (uTWEAK) levels might be predictive and/or diagnostic in LN. In a cross-sectional study of a large, multi-center cohort of systemic lupus erythematosus (SLE) patients, uTWEAK levels were higher in patients with active as compared to never or non-active nephritis (median (IQR): 16.3 (9.9-23.0) versus 5.5 (2.3-16.8) pg/mg creatinine, p = 0.001), and levels of uTWEAK correlated with the renal SLE disease activity index (rSLEDAI) score (r = 0.405, p < 0.001). uTWEAK levels were higher in patients undergoing a flare as compared to patients with chronic stable disease (11.1 (8.1-18.2) and 5.2 (2.3-15.3) pg/mg creatinine, respectively; p = 0.036). Moreover, uTWEAK levels were significantly higher in patients undergoing a renal flare, as opposed to a non-renal flare (12.4 (9.1-18.2) and 5.2 (3.0-11.9) pg/mg creatinine, respectively; p = 0.029). An accurate, non-invasive method to repeatedly assess kidney disease in lupus would be very helpful in managing these often challenging patients. Our study indicates that urinary TWEAK levels may be useful as a novel biomarker in LN.
KW - Lupus nephritis
KW - Systemic lupus erythematosus
KW - TWEAK
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UR - http://www.scopus.com/inward/citedby.url?scp=33846830051&partnerID=8YFLogxK
U2 - 10.1016/j.jaut.2006.12.003
DO - 10.1016/j.jaut.2006.12.003
M3 - Article
C2 - 17257812
AN - SCOPUS:33846830051
SN - 0896-8411
VL - 27
SP - 242
EP - 250
JO - Journal of Autoimmunity
JF - Journal of Autoimmunity
IS - 4
ER -