Abstract
PURPOSE OF REVIEW: Bladder cancer is one of the most common genitourinary malignancies and is a potentially life-threatening diagnosis. For many patients, however, the diagnosis of bladder cancer entails a lifetime of vigilant, costly, and invasive surveillance for recurrent and/or progressive disease. In the context of relative limitations of the current standard of cystoscopy and cytology, there has been burgeoning activity in the development of novel molecular urine-based markers for bladder cancer detection. RECENT FINDINGS: A large number of candidate bladder cancer biomarkers have emerged as our understanding of the molecular pathogenesis of the disease has evolved. Many of these are in the relatively earlier phases of development but several have received the approval of the United States Food and Drug Administration for clinical use and are already being applied to patients in clinical practice. SUMMARY: Urine-based markers for bladder cancer detection represent an area of substantial innovation and discovery with potentially profound scientific, clinical, and economic implications. As more of these tests become standardized and undergo evaluation in large multicenter trials, it is conceivable that a novel marker or panel of markers will emerge as a major enhancement to the current standard of care.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 350-355 |
| Number of pages | 6 |
| Journal | Current Opinion in Urology |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2006 |
| Externally published | Yes |
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Keywords
- Bladder cancer
- Detection
- Markers
- Surveillance
- Urine
ASJC Scopus subject areas
- Urology
Cite this
Urinary markers in the detection of bladder cancer : What's new? / Nielsen, Matthew E.; Schaeffer, Edward M.; Veltri, Robert W.; Schoenberg, Mark P.; Getzenberg, Robert H.
In: Current Opinion in Urology, Vol. 16, No. 5, 09.2006, p. 350-355.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Urinary markers in the detection of bladder cancer
T2 - What's new?
AU - Nielsen, Matthew E.
AU - Schaeffer, Edward M.
AU - Veltri, Robert W.
AU - Schoenberg, Mark P.
AU - Getzenberg, Robert H.
PY - 2006/9
Y1 - 2006/9
N2 - PURPOSE OF REVIEW: Bladder cancer is one of the most common genitourinary malignancies and is a potentially life-threatening diagnosis. For many patients, however, the diagnosis of bladder cancer entails a lifetime of vigilant, costly, and invasive surveillance for recurrent and/or progressive disease. In the context of relative limitations of the current standard of cystoscopy and cytology, there has been burgeoning activity in the development of novel molecular urine-based markers for bladder cancer detection. RECENT FINDINGS: A large number of candidate bladder cancer biomarkers have emerged as our understanding of the molecular pathogenesis of the disease has evolved. Many of these are in the relatively earlier phases of development but several have received the approval of the United States Food and Drug Administration for clinical use and are already being applied to patients in clinical practice. SUMMARY: Urine-based markers for bladder cancer detection represent an area of substantial innovation and discovery with potentially profound scientific, clinical, and economic implications. As more of these tests become standardized and undergo evaluation in large multicenter trials, it is conceivable that a novel marker or panel of markers will emerge as a major enhancement to the current standard of care.
AB - PURPOSE OF REVIEW: Bladder cancer is one of the most common genitourinary malignancies and is a potentially life-threatening diagnosis. For many patients, however, the diagnosis of bladder cancer entails a lifetime of vigilant, costly, and invasive surveillance for recurrent and/or progressive disease. In the context of relative limitations of the current standard of cystoscopy and cytology, there has been burgeoning activity in the development of novel molecular urine-based markers for bladder cancer detection. RECENT FINDINGS: A large number of candidate bladder cancer biomarkers have emerged as our understanding of the molecular pathogenesis of the disease has evolved. Many of these are in the relatively earlier phases of development but several have received the approval of the United States Food and Drug Administration for clinical use and are already being applied to patients in clinical practice. SUMMARY: Urine-based markers for bladder cancer detection represent an area of substantial innovation and discovery with potentially profound scientific, clinical, and economic implications. As more of these tests become standardized and undergo evaluation in large multicenter trials, it is conceivable that a novel marker or panel of markers will emerge as a major enhancement to the current standard of care.
KW - Bladder cancer
KW - Detection
KW - Markers
KW - Surveillance
KW - Urine
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U2 - 10.1097/01.mou.0000240308.62958.50
DO - 10.1097/01.mou.0000240308.62958.50
M3 - Article
C2 - 16905981
AN - SCOPUS:33747172001
VL - 16
SP - 350
EP - 355
JO - Current Opinion in Urology
JF - Current Opinion in Urology
SN - 0963-0643
IS - 5
ER -