Uptake of Genetic Testing by Relatives of Lynch Syndrome Probands

A Systematic Review

Ravi N. Sharaf, Parvathi A. Myer, Christopher D. Stave, Lisa C. Diamond, Uri Ladabaum

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background & Aims: Screening of persons with newly diagnosed colorectal cancer for Lynch syndrome can yield substantial benefits at acceptable costs, presuming sufficient uptake of genetic testing by first-degree relatives of Lynch syndrome probands. We performed a systematic review of the literature to determine the frequency of and factors associated with genetic testing of first-degree relatives of Lynch syndrome probands. Methods: We searched 4 databases (CINAHL, PsycInfo, PUBMED, and SCOPUS) for articles published through May 2011 reporting uptake of genetic testing by relatives of Lynch syndrome probands. Two investigators independently screened articles to determine whether they met inclusion criteria; data were collected on study population, genetic counseling, and genetic testing. A narrative, qualitative systematic review was performed. Results: We identified 1258 potentially relevant articles; 533 underwent full-text review, and 8 were included in the final analysis. Of first-degree relatives of Lynch syndrome probands, 52% or less received genetic testing. For each proband, 3.6 or fewer relatives underwent genetic testing. Demographic factors (age

Original languageEnglish (US)
Pages (from-to)1093-1100
Number of pages8
JournalClinical Gastroenterology and Hepatology
Volume11
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

Hereditary Nonpolyposis Colorectal Neoplasms
Genetic Testing
Genetic Counseling
Population Genetics
Colorectal Neoplasms
Research Personnel
Demography
Databases
Costs and Cost Analysis

Keywords

  • Colorectal Cancer
  • First-degree Relatives
  • Genetic Testing
  • Lynch Syndrome
  • Second-degree Relative

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Uptake of Genetic Testing by Relatives of Lynch Syndrome Probands : A Systematic Review. / Sharaf, Ravi N.; Myer, Parvathi A.; Stave, Christopher D.; Diamond, Lisa C.; Ladabaum, Uri.

In: Clinical Gastroenterology and Hepatology, Vol. 11, No. 9, 09.2013, p. 1093-1100.

Research output: Contribution to journalArticle

Sharaf, Ravi N. ; Myer, Parvathi A. ; Stave, Christopher D. ; Diamond, Lisa C. ; Ladabaum, Uri. / Uptake of Genetic Testing by Relatives of Lynch Syndrome Probands : A Systematic Review. In: Clinical Gastroenterology and Hepatology. 2013 ; Vol. 11, No. 9. pp. 1093-1100.
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