Update on pathogenesis, management, and control of Plasmodium vivax

Nazia Khan, Johanna P. Daily

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of reviewThis is a review of Plasmodium vivax epidemiology, pathogenesis, disease presentation, treatment and innovations in control and elimination. Here, we examine the recent literature and summarize new advances and ongoing challenges in the management of P. vivax.Recent findingsP. vivax has a complex life cycle in the human host which impacts disease severity and treatment regimens. There is increasing data for the presence of cryptic reservoirs in the spleen and bone marrow which may contribute to chronic vivax infections and possibly disease severity. Methods to map the geospatial epidemiology of P. vivax chloroquine resistance are advancing, and they will inform local treatment guidelines. P. vivax treatment requires an 8-aminoquinoline to eradicate the dormant liver stage. Evidence suggests that higher doses of 8-aminoquinolines may be needed for radical cure of tropical frequent-relapsing strains.SummaryP. vivax is a significant global health problem. There have been recent developments in understanding the complexity of P. vivax biology and optimization of antimalarial therapy. Studies toward the development of best practices for P. vivax control and elimination programs are ongoing.

Original languageEnglish (US)
Pages (from-to)404-409
Number of pages6
JournalCurrent Opinion in Infectious Diseases
Volume35
Issue number5
DOIs
StatePublished - Oct 1 2022

Keywords

  • 8-aminoquinoline
  • P. vivax drug resistance
  • P. vivax prevention
  • P. vivax treatment
  • Plasmodium vivax
  • Plasmodium vivax circumsporozoite protein (Pv CSP) vaccine development
  • cryptic infection
  • glucose-6-phosphate dehydrogenase deficiency
  • radical cure

ASJC Scopus subject areas

  • Medicine(all)

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