Unexpected immunoglobulin light chain gene rearrangements in myeloid antigen positive acute lymphoid leukemia

Elisabeth Paietta, Brian Van Ness, John M. Bennett, Camille Pellone, Daniel Billadeau, Peter A. Cassileth, Peter H. Wiernik

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Blast cells from 10 immunologically diagnosed adult acute lymphoid leukemias expressing myeloid antigens (M+ ALL) were studied for immunoglobulin heavy (IgH) and light chain as well as T-cell receptor (TCR)-β chain gene rearrangements. All but one leukemic isolate met the FAB criteria for ALL. DNA from 2 patients with pre-pre-B-ALL (CD10-) and 1 patient with common ALL contained rearranged Ig light chain (κ in two, λ in one case) in addition to rearranged IgH genes. The TCR-β chain gene was germline in all pre-pre-B leukemias and rearranged in common ALLs (bigenotypic features). One patient with mature B-ALL showed IgH and light chain gene rearrangements. DNA from 2 pre-T-ALLs contained rearranged TCR-β chain genes plus rearranged IgH genes in one case. Ig light chain gene rearrangements in immature M+ ALL were not associated with gross chromosomal abnormalities except for one Philadelphia chromosome positive case. The occurrence of Ig light chain gene rearrangements in M- ALL with immature lymphoid immunophenotype might represent an hitherto unrecognized aberrant differentiation potential of transformed multipotential stem cells with commitment towards the lymphoid lineage.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalLeukemia Research
Volume15
Issue number2-3
DOIs
StatePublished - 1991

Keywords

  • Acute lymphoid leukemia
  • genotype
  • myeloid antigen

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Paietta, E., Van Ness, B., Bennett, J. M., Pellone, C., Billadeau, D., Cassileth, P. A., & Wiernik, P. H. (1991). Unexpected immunoglobulin light chain gene rearrangements in myeloid antigen positive acute lymphoid leukemia. Leukemia Research, 15(2-3), 149-155. https://doi.org/10.1016/0145-2126(91)90096-C