Under what circumstances can seizures produce hippocampal injury

Evidence for age-specific effects

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Mesial temporal sclerosis (MTS) is the characteristic hippocampal pathology of temporal lobe epilepsy in adults. Both clinical and experimental studies indicate that although the immature brain is highly susceptible to seizures, it is more resistant to the development of the seizure-induced hippocampal pathology akin to MTS, compared with the adult brain. However, seizures in the immature brain may produce age-specific effects on hippocampal morphology or function. The spectrum of these effects is still unknown. Factors such as the presence of prior neurological abnormalities, age, etiology of the seizures, repetitive seizures and genetic predisposition may affect the range and severity of hippocampal changes. The key point is to identify the significance of these changes and design age-appropriate preventative treatments.

Original languageEnglish (US)
Pages (from-to)355-363
Number of pages9
JournalDevelopmental Neuroscience
Volume24
Issue number5
DOIs
StatePublished - 2002

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Seizures
Wounds and Injuries
Sclerosis
Brain
Pathology
Temporal Lobe Epilepsy
Genetic Predisposition to Disease

Keywords

  • Adult
  • Epilepsy
  • Febrile seizure
  • Hippocampus
  • Immature
  • Mesial temporal sclerosis
  • Neuroprotection
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Under what circumstances can seizures produce hippocampal injury: Evidence for age-specific effects",
abstract = "Mesial temporal sclerosis (MTS) is the characteristic hippocampal pathology of temporal lobe epilepsy in adults. Both clinical and experimental studies indicate that although the immature brain is highly susceptible to seizures, it is more resistant to the development of the seizure-induced hippocampal pathology akin to MTS, compared with the adult brain. However, seizures in the immature brain may produce age-specific effects on hippocampal morphology or function. The spectrum of these effects is still unknown. Factors such as the presence of prior neurological abnormalities, age, etiology of the seizures, repetitive seizures and genetic predisposition may affect the range and severity of hippocampal changes. The key point is to identify the significance of these changes and design age-appropriate preventative treatments.",
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AU - Galanopoulou, Aristea S.

AU - Vidaurre, Jorge

AU - Moshe, Solomon L.

PY - 2002

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N2 - Mesial temporal sclerosis (MTS) is the characteristic hippocampal pathology of temporal lobe epilepsy in adults. Both clinical and experimental studies indicate that although the immature brain is highly susceptible to seizures, it is more resistant to the development of the seizure-induced hippocampal pathology akin to MTS, compared with the adult brain. However, seizures in the immature brain may produce age-specific effects on hippocampal morphology or function. The spectrum of these effects is still unknown. Factors such as the presence of prior neurological abnormalities, age, etiology of the seizures, repetitive seizures and genetic predisposition may affect the range and severity of hippocampal changes. The key point is to identify the significance of these changes and design age-appropriate preventative treatments.

AB - Mesial temporal sclerosis (MTS) is the characteristic hippocampal pathology of temporal lobe epilepsy in adults. Both clinical and experimental studies indicate that although the immature brain is highly susceptible to seizures, it is more resistant to the development of the seizure-induced hippocampal pathology akin to MTS, compared with the adult brain. However, seizures in the immature brain may produce age-specific effects on hippocampal morphology or function. The spectrum of these effects is still unknown. Factors such as the presence of prior neurological abnormalities, age, etiology of the seizures, repetitive seizures and genetic predisposition may affect the range and severity of hippocampal changes. The key point is to identify the significance of these changes and design age-appropriate preventative treatments.

KW - Adult

KW - Epilepsy

KW - Febrile seizure

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KW - Immature

KW - Mesial temporal sclerosis

KW - Neuroprotection

KW - Rat

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