Uncovering the mechanisms that regulate tumor-induced T-cell anergy

Brian T. Abe, Fernando Macian

Research output: Contribution to journalComment/debatepeer-review

14 Scopus citations


Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy.

Original languageEnglish (US)
Article numbere22679
Issue number2
StatePublished - Feb 2013


  • Anergy
  • Immune evasion
  • Melanoma
  • NFAT
  • T helper cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology


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