Uncovering the mechanisms that regulate tumor-induced T-cell anergy

Brian T. Abe; Fernando Macian

doi:10.4161/onci.22679

Uncovering the mechanisms that regulate tumor-induced T-cell anergy

Brian T. Abe, Fernando Macian

Pathology

Research output: Contribution to journal › Comment/debate › peer-review

16 Scopus citations

Abstract

Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy.

Original language	English (US)
Article number	e22679
Journal	OncoImmunology
Volume	2
Issue number	2
DOIs	https://doi.org/10.4161/onci.22679
State	Published - Feb 2013

Keywords

Anergy
Immune evasion
Melanoma
NFAT
T helper cell

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.22679

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title = "Uncovering the mechanisms that regulate tumor-induced T-cell anergy",

abstract = "Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy.",

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AB - Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy.

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KW - Immune evasion

KW - Melanoma

KW - NFAT

KW - T helper cell

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M3 - Comment/debate

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JF - OncoImmunology

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M1 - e22679

ER -

Uncovering the mechanisms that regulate tumor-induced T-cell anergy

Abstract

Keywords

ASJC Scopus subject areas

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