Uncovering the mechanisms that regulate tumor-induced T-cell anergy

Brian T. Abe, Fernando Macian-Juan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy.

Original languageEnglish (US)
Article numbere22679
JournalOncoImmunology
Volume2
Issue number2
DOIs
StatePublished - Feb 2013

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Tumor Microenvironment
Helper-Inducer T-Lymphocytes
Immunotherapy
T-Lymphocytes
Genes
Neoplasms

Keywords

  • Anergy
  • Immune evasion
  • Melanoma
  • NFAT
  • T helper cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

Uncovering the mechanisms that regulate tumor-induced T-cell anergy. / Abe, Brian T.; Macian-Juan, Fernando.

In: OncoImmunology, Vol. 2, No. 2, e22679, 02.2013.

Research output: Contribution to journalArticle

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