Uncommon Endoscopic Findings in a Tylosis Patient: A Case Report

Balarama K. Surapaneni, Pragnan Kancharla, R. Vinayek, Sudhir K. Dutta, Mendel Goldfinger

Research output: Contribution to journalArticle

Abstract

Palmoplantar tylosis is a focal non epidermolytic palmoplantar hyperkeratosis and is associated with a very high lifetime risk of developing squamous cell carcinoma of the esophagus (OSCC). It is generally inherited as an autosomal dominant trait with complete penetrance involving the RHBDF2 gene located on 17q25.1. The data regarding endoscopic appearance of the mucosa in patients with tylosis before development of cancer is limited. Surveillance endoscopy is recommended in family members which include annual esophagogastroscopy with biopsy of suspicious lesion with quadratic biopsies from upper, middle and lower esophagus. We describe characteristic endoscopy findings in a tylosis with no evidence of cancer. Prospective documentation of endoscopic findings of similar mucosal changes and disease process to establish a better screening protocol and supplemental intervention with agents like carotenoids (beta-carotene, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin) may delay the progression and possibly revert to normal.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalCase Reports in Oncology
Volume12
Issue number2
DOIs
StatePublished - May 1 2019
Externally publishedYes

Fingerprint

Keratoderma, Palmoplantar, Diffuse
Esophagus
Endoscopy
Epidermolytic Hyperkeratosis
Biopsy
Lutein
Penetrance
beta Carotene
Carotenoids
Documentation
Squamous Cell Carcinoma
Neoplasms
Mucous Membrane
Genes

Keywords

  • Endoscopy
  • Esophageal cancer
  • Tylosis

ASJC Scopus subject areas

  • Oncology

Cite this

Uncommon Endoscopic Findings in a Tylosis Patient : A Case Report. / Surapaneni, Balarama K.; Kancharla, Pragnan; Vinayek, R.; Dutta, Sudhir K.; Goldfinger, Mendel.

In: Case Reports in Oncology, Vol. 12, No. 2, 01.05.2019, p. 385-390.

Research output: Contribution to journalArticle

Surapaneni, BK, Kancharla, P, Vinayek, R, Dutta, SK & Goldfinger, M 2019, 'Uncommon Endoscopic Findings in a Tylosis Patient: A Case Report', Case Reports in Oncology, vol. 12, no. 2, pp. 385-390. https://doi.org/10.1159/000500082
Surapaneni, Balarama K. ; Kancharla, Pragnan ; Vinayek, R. ; Dutta, Sudhir K. ; Goldfinger, Mendel. / Uncommon Endoscopic Findings in a Tylosis Patient : A Case Report. In: Case Reports in Oncology. 2019 ; Vol. 12, No. 2. pp. 385-390.
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