TY - JOUR
T1 - Two-year surveillance on fluconazole susceptibility of Candida spp isolates in a general and university hospital in Rome
AU - Piero Testore, Gian
AU - Falco, Fulvio
AU - Sarrecchia, Cesare
AU - Sordillo, Pasquale
AU - Bontempo, Gilda
AU - Andreoni, Massimo
N1 - Funding Information:
We thanks Mrs. Patrizia Amadei, Mrs. Annamaria Buonomini and Mr. Luca Dori for their technical help. This work was supported in part by a grant of Pfizer Italiana SpA.
PY - 2001
Y1 - 2001
N2 - Fluconazole susceptibility was tested in 385 clinical yeast isolates (285 Candida albicans, 38 C.glabrata, 31 C.tropicalis, 31 other Candida subsp.) using the agar disk diffusion test. Yeasts were collected from specimens obtained from outpatients (69) and inpatients (intensive care unit: 79 isolates, major burn unit: 31 isolates, hematology ward: 45 isolates, gynecology ward: 67 isolates, other wards: 94 isolates). Three hundred and fifty-six (92%) yeast isolates showed to be susceptible, 18 (5%) were susceptible dose-dependent, and 10 (3%) were resistant to fluconazole. Of the resistant group, 3 isolates were C.albicans, while seven were Candida non-albicans (2 C.rugosa, 2 C.humicola, 1 C.tropicalis, 1 C.ciferrii, 1 C.glabrata). The disk-diffusion method was easy to perform and there were no difficulties in the interpretation of inhibition zone diameters. Fluconazole maintained a good activity against Candida spp despite its extensive use for the prophylaxis and treatment of fungal infections.
AB - Fluconazole susceptibility was tested in 385 clinical yeast isolates (285 Candida albicans, 38 C.glabrata, 31 C.tropicalis, 31 other Candida subsp.) using the agar disk diffusion test. Yeasts were collected from specimens obtained from outpatients (69) and inpatients (intensive care unit: 79 isolates, major burn unit: 31 isolates, hematology ward: 45 isolates, gynecology ward: 67 isolates, other wards: 94 isolates). Three hundred and fifty-six (92%) yeast isolates showed to be susceptible, 18 (5%) were susceptible dose-dependent, and 10 (3%) were resistant to fluconazole. Of the resistant group, 3 isolates were C.albicans, while seven were Candida non-albicans (2 C.rugosa, 2 C.humicola, 1 C.tropicalis, 1 C.ciferrii, 1 C.glabrata). The disk-diffusion method was easy to perform and there were no difficulties in the interpretation of inhibition zone diameters. Fluconazole maintained a good activity against Candida spp despite its extensive use for the prophylaxis and treatment of fungal infections.
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U2 - 10.1016/S0732-8893(01)00280-2
DO - 10.1016/S0732-8893(01)00280-2
M3 - Article
C2 - 11687310
AN - SCOPUS:0034772916
SN - 0732-8893
VL - 41
SP - 23
EP - 27
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 1-2
ER -
