Two-year outcomes of surgical treatment of moderate ischemic mitral regurgitation

Robert E. Michler, Peter K. Smith, Michael K. Parides, Gorav Ailawadi, Vinod Thourani, Alan J. Moskowitz, Michael A. Acker, Judy W. Hung, Helena L. Chang, Louis P. Perrault, A. Marc Gillinov, Michael Argenziano, Emilia Bagiella, Jessica R. Overbey, Ellen G. Moquete, Lopa N. Gupta, Marissa A. Miller, Wendy C. Taddei-Peters, Neal Jeffries, Richard D. WeiselEric A. Rose, James S. Gammie, Joseph DeRose, John D. Puskas, François Dagenais, Sandra G. Burks, Ismail El-Hamamsy, Carmelo A. Milano, Pavan Atluri, Pierre Voisine, Patrick T. O'Gara, Annetine C. Gelijns

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Abstract

BACKGROUND: In a trial comparing coronary-artery bypass grafting (CABG) alone with CABG plus mitral-valve repair in patients with moderate ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index (LVESVI) or survival after 1 year. Concomitant mitral-valve repair was associated with a reduced prevalence of moderate or severe mitral regurgitation, but patients had more adverse events. We now report 2-year outcomes. METHODS: We randomly assigned 301 patients to undergo either CABG alone or the combined procedure. Patients were followed for 2 years for clinical and echocardiographic outcomes. RESULTS: At 2 years, the mean (±SD) LVESVI was 41.2±20.0 ml per square meter of bodysurface area in the CABG-alone group and 43.2±20.6 ml per square meter in the combined-procedure group (mean improvement over baseline, -14.1 ml per square meter and -14.6 ml per square meter, respectively). The rate of death was 10.6% in the CABG-alone group and 10.0% in the combined-procedure group (hazard ratio in the combined-procedure group, 0.90; 95% confidence interval, 0.45 to 1.83; P = 0.78). There was no significant between-group difference in the rank-based assessment of the LVESVI (including death) at 2 years (z score, 0.38; P = 0.71). The 2-year rate of moderate or severe residual mitral regurgitation was higher in the CABG-alone group than in the combined-procedure group (32.3% vs. 11.2%, P

Original languageEnglish (US)
Pages (from-to)1932-1941
Number of pages10
JournalNew England Journal of Medicine
Volume374
Issue number20
DOIs
StatePublished - May 19 2016

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Mitral Valve Insufficiency
Coronary Artery Bypass
Stroke Volume
Mitral Valve
Confidence Intervals
Survival
Mortality

ASJC Scopus subject areas

  • Medicine(all)

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Two-year outcomes of surgical treatment of moderate ischemic mitral regurgitation. / Michler, Robert E.; Smith, Peter K.; Parides, Michael K.; Ailawadi, Gorav; Thourani, Vinod; Moskowitz, Alan J.; Acker, Michael A.; Hung, Judy W.; Chang, Helena L.; Perrault, Louis P.; Gillinov, A. Marc; Argenziano, Michael; Bagiella, Emilia; Overbey, Jessica R.; Moquete, Ellen G.; Gupta, Lopa N.; Miller, Marissa A.; Taddei-Peters, Wendy C.; Jeffries, Neal; Weisel, Richard D.; Rose, Eric A.; Gammie, James S.; DeRose, Joseph; Puskas, John D.; Dagenais, François; Burks, Sandra G.; El-Hamamsy, Ismail; Milano, Carmelo A.; Atluri, Pavan; Voisine, Pierre; O'Gara, Patrick T.; Gelijns, Annetine C.

In: New England Journal of Medicine, Vol. 374, No. 20, 19.05.2016, p. 1932-1941.

Research output: Contribution to journalArticle

Michler, RE, Smith, PK, Parides, MK, Ailawadi, G, Thourani, V, Moskowitz, AJ, Acker, MA, Hung, JW, Chang, HL, Perrault, LP, Gillinov, AM, Argenziano, M, Bagiella, E, Overbey, JR, Moquete, EG, Gupta, LN, Miller, MA, Taddei-Peters, WC, Jeffries, N, Weisel, RD, Rose, EA, Gammie, JS, DeRose, J, Puskas, JD, Dagenais, F, Burks, SG, El-Hamamsy, I, Milano, CA, Atluri, P, Voisine, P, O'Gara, PT & Gelijns, AC 2016, 'Two-year outcomes of surgical treatment of moderate ischemic mitral regurgitation', New England Journal of Medicine, vol. 374, no. 20, pp. 1932-1941. https://doi.org/10.1056/NEJMoa1602003
Michler, Robert E. ; Smith, Peter K. ; Parides, Michael K. ; Ailawadi, Gorav ; Thourani, Vinod ; Moskowitz, Alan J. ; Acker, Michael A. ; Hung, Judy W. ; Chang, Helena L. ; Perrault, Louis P. ; Gillinov, A. Marc ; Argenziano, Michael ; Bagiella, Emilia ; Overbey, Jessica R. ; Moquete, Ellen G. ; Gupta, Lopa N. ; Miller, Marissa A. ; Taddei-Peters, Wendy C. ; Jeffries, Neal ; Weisel, Richard D. ; Rose, Eric A. ; Gammie, James S. ; DeRose, Joseph ; Puskas, John D. ; Dagenais, François ; Burks, Sandra G. ; El-Hamamsy, Ismail ; Milano, Carmelo A. ; Atluri, Pavan ; Voisine, Pierre ; O'Gara, Patrick T. ; Gelijns, Annetine C. / Two-year outcomes of surgical treatment of moderate ischemic mitral regurgitation. In: New England Journal of Medicine. 2016 ; Vol. 374, No. 20. pp. 1932-1941.
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T1 - Two-year outcomes of surgical treatment of moderate ischemic mitral regurgitation

AU - Michler, Robert E.

AU - Smith, Peter K.

AU - Parides, Michael K.

AU - Ailawadi, Gorav

AU - Thourani, Vinod

AU - Moskowitz, Alan J.

AU - Acker, Michael A.

AU - Hung, Judy W.

AU - Chang, Helena L.

AU - Perrault, Louis P.

AU - Gillinov, A. Marc

AU - Argenziano, Michael

AU - Bagiella, Emilia

AU - Overbey, Jessica R.

AU - Moquete, Ellen G.

AU - Gupta, Lopa N.

AU - Miller, Marissa A.

AU - Taddei-Peters, Wendy C.

AU - Jeffries, Neal

AU - Weisel, Richard D.

AU - Rose, Eric A.

AU - Gammie, James S.

AU - DeRose, Joseph

AU - Puskas, John D.

AU - Dagenais, François

AU - Burks, Sandra G.

AU - El-Hamamsy, Ismail

AU - Milano, Carmelo A.

AU - Atluri, Pavan

AU - Voisine, Pierre

AU - O'Gara, Patrick T.

AU - Gelijns, Annetine C.

PY - 2016/5/19

Y1 - 2016/5/19

N2 - BACKGROUND: In a trial comparing coronary-artery bypass grafting (CABG) alone with CABG plus mitral-valve repair in patients with moderate ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index (LVESVI) or survival after 1 year. Concomitant mitral-valve repair was associated with a reduced prevalence of moderate or severe mitral regurgitation, but patients had more adverse events. We now report 2-year outcomes. METHODS: We randomly assigned 301 patients to undergo either CABG alone or the combined procedure. Patients were followed for 2 years for clinical and echocardiographic outcomes. RESULTS: At 2 years, the mean (±SD) LVESVI was 41.2±20.0 ml per square meter of bodysurface area in the CABG-alone group and 43.2±20.6 ml per square meter in the combined-procedure group (mean improvement over baseline, -14.1 ml per square meter and -14.6 ml per square meter, respectively). The rate of death was 10.6% in the CABG-alone group and 10.0% in the combined-procedure group (hazard ratio in the combined-procedure group, 0.90; 95% confidence interval, 0.45 to 1.83; P = 0.78). There was no significant between-group difference in the rank-based assessment of the LVESVI (including death) at 2 years (z score, 0.38; P = 0.71). The 2-year rate of moderate or severe residual mitral regurgitation was higher in the CABG-alone group than in the combined-procedure group (32.3% vs. 11.2%, P

AB - BACKGROUND: In a trial comparing coronary-artery bypass grafting (CABG) alone with CABG plus mitral-valve repair in patients with moderate ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index (LVESVI) or survival after 1 year. Concomitant mitral-valve repair was associated with a reduced prevalence of moderate or severe mitral regurgitation, but patients had more adverse events. We now report 2-year outcomes. METHODS: We randomly assigned 301 patients to undergo either CABG alone or the combined procedure. Patients were followed for 2 years for clinical and echocardiographic outcomes. RESULTS: At 2 years, the mean (±SD) LVESVI was 41.2±20.0 ml per square meter of bodysurface area in the CABG-alone group and 43.2±20.6 ml per square meter in the combined-procedure group (mean improvement over baseline, -14.1 ml per square meter and -14.6 ml per square meter, respectively). The rate of death was 10.6% in the CABG-alone group and 10.0% in the combined-procedure group (hazard ratio in the combined-procedure group, 0.90; 95% confidence interval, 0.45 to 1.83; P = 0.78). There was no significant between-group difference in the rank-based assessment of the LVESVI (including death) at 2 years (z score, 0.38; P = 0.71). The 2-year rate of moderate or severe residual mitral regurgitation was higher in the CABG-alone group than in the combined-procedure group (32.3% vs. 11.2%, P

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