Two examples of an inseparable antibody that reacts equally well with D(W)+ and Rh32+ red blood cells

Marion E. Reid, Laima Sausais, Charles G. Zaroulis, Kala Mohandas, Gail Coghlan, Christine Lomas-Francis

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Background and Objectives: Anti-D(W) is a rare specificity that detects an antigen on D(Va) red blood cells (RBCs). Some anti-D(W) contain an inseparable component that cross-reacts weakly with RBCs expressing the low-incidence Rh antigen Rh32. RH32 is expressed by RBCs with either the R@?(N) or the DBT phenotype. Case Report: We describe here an antibody found in the serum of 2 patients that reacts equally well with RBCs possessing either D(Va), R@?(N), or DBT phenotypes. The reactivity for D(W) and Rh32 antigens could not be separated by adsorption onto and elution from D(W)+Rh32- or from D(W)-Rh32+ RBCs. Conclusions: We suggest that amino acids encoded by nucleotides at the junction of exon 4 of RHD to exon 5 of RHCE may induce a conformation that is recognized by these equally reactive inseparable antibodies. Until such time that the epitope recognized by these antibodies is defined, we recommend use of the descriptive name anti-D(W)/Rh32.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalVox Sanguinis
Issue number3
Publication statusPublished - Jan 1 1998
Externally publishedYes


ASJC Scopus subject areas

  • Hematology

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