Twenty four hour secretory patterns of gonadotropins and prolactin in a case of Chiari Frommel syndrome

S. Kapen, R. Boyar, R. Freeman, A. Frantz, L. Hellman, E. D. Weitzman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Plasma LH (luteinizing hormone) FSH (follicle stimulating hormone) and prolactin secretory patterns were derived from the measurement of 20 min interval plasma samples obtained during a complete 24 hr period in a patient with persistent postpartum amenorrhea and galactorrhea (Chiari Frommel syndrome), before and after clomiphene citrate therapy. During nocturnal sleep, polygraphic monitoring was carried out to precisely identify sleep onset, specific sleep stages and waking periods. During the evening and nighttime hours, LH and FSH concentrations were markedly reduced, compared to the daytime patterns both before and after clomiphene therapy. A sleep associated rise of prolactin concentration was present, similar to the pattern found in normal subjects but at higher concentrations. The reciprocal nature of the nocturnal secretory patterns for LH and FSH and prolactin in this patient suggests an alteration in hypothalamic dopaminergic mechanisms which are thought to control the secretion of these hormones.

Original languageEnglish (US)
Pages (from-to)234-239
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume40
Issue number2
StatePublished - 1975

Fingerprint

Chiari-Frommel Syndrome
Follicle Stimulating Hormone
Luteinizing Hormone
Gonadotropins
Prolactin
Clomiphene
Sleep
Galactorrhea
Sleep Stages
Amenorrhea
Plasmas
Hormones
Therapeutics
Monitoring

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Kapen, S., Boyar, R., Freeman, R., Frantz, A., Hellman, L., & Weitzman, E. D. (1975). Twenty four hour secretory patterns of gonadotropins and prolactin in a case of Chiari Frommel syndrome. Journal of Clinical Endocrinology and Metabolism, 40(2), 234-239.

Twenty four hour secretory patterns of gonadotropins and prolactin in a case of Chiari Frommel syndrome. / Kapen, S.; Boyar, R.; Freeman, R.; Frantz, A.; Hellman, L.; Weitzman, E. D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 40, No. 2, 1975, p. 234-239.

Research output: Contribution to journalArticle

Kapen, S, Boyar, R, Freeman, R, Frantz, A, Hellman, L & Weitzman, ED 1975, 'Twenty four hour secretory patterns of gonadotropins and prolactin in a case of Chiari Frommel syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 40, no. 2, pp. 234-239.
Kapen, S. ; Boyar, R. ; Freeman, R. ; Frantz, A. ; Hellman, L. ; Weitzman, E. D. / Twenty four hour secretory patterns of gonadotropins and prolactin in a case of Chiari Frommel syndrome. In: Journal of Clinical Endocrinology and Metabolism. 1975 ; Vol. 40, No. 2. pp. 234-239.
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