Turner's Syndrome and Inflammatory Bowel Disease: A Case Report with Immunologic Studies

N. C. Manzione, M. Kram, E. Kram, K. M. Das

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A patient with Turner's syndrome who developed ulcerative colitis (UC) is reported, and reports from the literature of 16 cases of Turner's syndrome with inflammatory bowel disease (IBD) are reviewed. Most of the patients previously described bad severe disease. Half of the patients bad ulcerative colitis and half bad Crohn's disease (CD). Of those with Crohn's, most bad colonic involvement. Of note, also, half of the patients bad an isochromosome for the long arm of X which usually is found in only 17% of all patients with Turner's syndrome. A high incidence of autoimmune diseases is associated with this syndrome. We demonstrate the presence of specific anticolonic antibodies in this patient and propose some possible explanations for the association of this particular chromosomal disorder with autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)1294-1297
Number of pages4
JournalThe American Journal of Gastroenterology
Volume83
Issue number11
DOIs
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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