Tumor cells caught in the act of invading: Their strategy for enhanced cell motility

Weigang Wang; Sumanta Goswami; Erik Sahai; Jeffrey B. Wyckoff; Jeffrey E. Segall; John S. Condeelis

doi:10.1016/j.tcb.2005.01.003

Tumor cells caught in the act of invading: Their strategy for enhanced cell motility

Weigang Wang, Sumanta Goswami, Erik Sahai, Jeffrey B. Wyckoff, Jeffrey E. Segall, John S. Condeelis

Research output: Contribution to journal › Article › peer-review

227 Scopus citations

Abstract

Invasion of neighboring extracellular matrix tissue, the lymphatic system and blood vessels is a key element of tumor cell metastasis in many epithelial tumors. Understanding the cell motility pathways that contribute to invasion can provide new approaches and targets for anticancer therapy. The recent convergence of technologies for expression profiling and intravital imaging has revealed the identities of some of the genes that contribute to motility and chemotaxis of cancer cells in tumors. In particular, the genes encoding a minimum motility machine are coordinately upregulated in tumor cells collected by an in vivo invasion assay. These results support a 'tumor microenvironment invasion model' and provide new target opportunities for cancer therapy.

Original language	English (US)
Pages (from-to)	138-145
Number of pages	8
Journal	Trends in Cell Biology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.tcb.2005.01.003
State	Published - Mar 2005

ASJC Scopus subject areas

Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2005.01.003

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title = "Tumor cells caught in the act of invading: Their strategy for enhanced cell motility",

abstract = "Invasion of neighboring extracellular matrix tissue, the lymphatic system and blood vessels is a key element of tumor cell metastasis in many epithelial tumors. Understanding the cell motility pathways that contribute to invasion can provide new approaches and targets for anticancer therapy. The recent convergence of technologies for expression profiling and intravital imaging has revealed the identities of some of the genes that contribute to motility and chemotaxis of cancer cells in tumors. In particular, the genes encoding a minimum motility machine are coordinately upregulated in tumor cells collected by an in vivo invasion assay. These results support a 'tumor microenvironment invasion model' and provide new target opportunities for cancer therapy.",

author = "Weigang Wang and Sumanta Goswami and Erik Sahai and Wyckoff, {Jeffrey B.} and Segall, {Jeffrey E.} and Condeelis, {John S.}",

note = "Funding Information: This activity was funded by a grant from the National Cancer Institute (CA 100324). E.S. is funded by Cancer Research UK. ",

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AU - Wang, Weigang

AU - Goswami, Sumanta

AU - Sahai, Erik

AU - Wyckoff, Jeffrey B.

AU - Segall, Jeffrey E.

AU - Condeelis, John S.

N1 - Funding Information: This activity was funded by a grant from the National Cancer Institute (CA 100324). E.S. is funded by Cancer Research UK.

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AB - Invasion of neighboring extracellular matrix tissue, the lymphatic system and blood vessels is a key element of tumor cell metastasis in many epithelial tumors. Understanding the cell motility pathways that contribute to invasion can provide new approaches and targets for anticancer therapy. The recent convergence of technologies for expression profiling and intravital imaging has revealed the identities of some of the genes that contribute to motility and chemotaxis of cancer cells in tumors. In particular, the genes encoding a minimum motility machine are coordinately upregulated in tumor cells collected by an in vivo invasion assay. These results support a 'tumor microenvironment invasion model' and provide new target opportunities for cancer therapy.

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Tumor cells caught in the act of invading: Their strategy for enhanced cell motility

Abstract

ASJC Scopus subject areas

UN SDGs

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