Trypanosoma cruzi: Inhibition of protein synthesis by nitrofuran SQ 18,506

Joseph L. Gugliotta, Herbert B. Tanowitz, Murray Wittner, Ruy Soeiro

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

SQ 18,506 is a nitrofuran compound related to the trypanocide Lampit. In vitro, radiolabeled leucine, uridine, and thymidine were incorporated into macromolecular protein, RNA, and DNA in order to study growth inhibition of Trypanosoma cruzi. Our findings suggest that the primary effect of the drug is on protein synthesis and not mediated solely by inhibition of RNA synthesis as indicated by prior studies. The drug was also found to reduce markedly the uptake of uridine into the nucleotide precursor pool but to affect only slightly the formation of aminoacyl-tRNA.

Original languageEnglish (US)
Pages (from-to)216-224
Number of pages9
JournalExperimental Parasitology
Volume49
Issue number2
DOIs
StatePublished - Apr 1980

Keywords

  • Chagas' disease
  • DNA synthesis
  • Hemoflagellate
  • Nitrofuran derivative SQ 18,506
  • Protein synthesis
  • Protozoa, parasitic
  • RNA synthesis
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases

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