Trypanosoma cruzi: Inhibition of protein synthesis by nitrofuran SQ 18,506

Joseph L. Gugliotta; Herbert B. Tanowitz; Murray Wittner; Ruy Soeiro

doi:10.1016/0014-4894(80)90118-6

Trypanosoma cruzi: Inhibition of protein synthesis by nitrofuran SQ 18,506

Joseph L. Gugliotta, Herbert B. Tanowitz, Murray Wittner, Ruy Soeiro

Pathology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

SQ 18,506 is a nitrofuran compound related to the trypanocide Lampit. In vitro, radiolabeled leucine, uridine, and thymidine were incorporated into macromolecular protein, RNA, and DNA in order to study growth inhibition of Trypanosoma cruzi. Our findings suggest that the primary effect of the drug is on protein synthesis and not mediated solely by inhibition of RNA synthesis as indicated by prior studies. The drug was also found to reduce markedly the uptake of uridine into the nucleotide precursor pool but to affect only slightly the formation of aminoacyl-tRNA.

Original language	English (US)
Pages (from-to)	216-224
Number of pages	9
Journal	Experimental Parasitology
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/0014-4894(80)90118-6
State	Published - Apr 1980

Keywords

Chagas' disease
DNA synthesis
Hemoflagellate
Nitrofuran derivative SQ 18,506
Protein synthesis
Protozoa, parasitic
RNA synthesis
Trypanosoma cruzi

ASJC Scopus subject areas

Parasitology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-4894(80)90118-6

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title = "Trypanosoma cruzi: Inhibition of protein synthesis by nitrofuran SQ 18,506",

abstract = "SQ 18,506 is a nitrofuran compound related to the trypanocide Lampit. In vitro, radiolabeled leucine, uridine, and thymidine were incorporated into macromolecular protein, RNA, and DNA in order to study growth inhibition of Trypanosoma cruzi. Our findings suggest that the primary effect of the drug is on protein synthesis and not mediated solely by inhibition of RNA synthesis as indicated by prior studies. The drug was also found to reduce markedly the uptake of uridine into the nucleotide precursor pool but to affect only slightly the formation of aminoacyl-tRNA.",

keywords = "Chagas' disease, DNA synthesis, Hemoflagellate, Nitrofuran derivative SQ 18,506, Protein synthesis, Protozoa, parasitic, RNA synthesis, Trypanosoma cruzi",

author = "Gugliotta, {Joseph L.} and Tanowitz, {Herbert B.} and Murray Wittner and Ruy Soeiro",

note = "Funding Information: This work was supported in part by Grant AI 12770, Training Grant Al 00405, and Ca 10993 from the U.S. National Institutes of Health. The authors wish to thank Dr. Barry Bloom for his continuing support of tropical disease research.",

year = "1980",

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doi = "10.1016/0014-4894(80)90118-6",

language = "English (US)",

volume = "49",

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journal = "Experimental Parasitology",

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T2 - Inhibition of protein synthesis by nitrofuran SQ 18,506

AU - Gugliotta, Joseph L.

AU - Tanowitz, Herbert B.

AU - Wittner, Murray

AU - Soeiro, Ruy

N1 - Funding Information: This work was supported in part by Grant AI 12770, Training Grant Al 00405, and Ca 10993 from the U.S. National Institutes of Health. The authors wish to thank Dr. Barry Bloom for his continuing support of tropical disease research.

PY - 1980/4

Y1 - 1980/4

N2 - SQ 18,506 is a nitrofuran compound related to the trypanocide Lampit. In vitro, radiolabeled leucine, uridine, and thymidine were incorporated into macromolecular protein, RNA, and DNA in order to study growth inhibition of Trypanosoma cruzi. Our findings suggest that the primary effect of the drug is on protein synthesis and not mediated solely by inhibition of RNA synthesis as indicated by prior studies. The drug was also found to reduce markedly the uptake of uridine into the nucleotide precursor pool but to affect only slightly the formation of aminoacyl-tRNA.

AB - SQ 18,506 is a nitrofuran compound related to the trypanocide Lampit. In vitro, radiolabeled leucine, uridine, and thymidine were incorporated into macromolecular protein, RNA, and DNA in order to study growth inhibition of Trypanosoma cruzi. Our findings suggest that the primary effect of the drug is on protein synthesis and not mediated solely by inhibition of RNA synthesis as indicated by prior studies. The drug was also found to reduce markedly the uptake of uridine into the nucleotide precursor pool but to affect only slightly the formation of aminoacyl-tRNA.

KW - Chagas' disease

KW - DNA synthesis

KW - Hemoflagellate

KW - Nitrofuran derivative SQ 18,506

KW - Protein synthesis

KW - Protozoa, parasitic

KW - RNA synthesis

KW - Trypanosoma cruzi

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ER -

Trypanosoma cruzi: Inhibition of protein synthesis by nitrofuran SQ 18,506

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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