Trypanosoma cruzi infection results in the reduced expression of caveolin-3 in the heart

Daniel Adesse, Michael P. Lisanti, David C. Spray, Fabiana S. Machado, Maria De Nazareth Meirelles, Herbert B. Tanowitz, Luciana Ribeiro Garzoni

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Caveolae are motile, membrane-bound compartments that contain a number of molecules that participate in cell signaling. Caveolins are protein markers of caveolae and function in a variety of biological processes. Caveolin-3 (Cav-3) is expressed in muscle cells and Cav-3 null mice display a cardiomyopathic phenotype. Ultrastructural cytochemistry, confocal microscopy and immunoblotting revealed a reduction in Cav-3 expression and an activation of eRK (extracellularsignal-regulated kinase) 48 hours after Trypanosoma cruzi infection of cultured cardiac myocytes. CD-1 mice infected with the Brazil strain of T. cruzi displayed reduced expression of Cav-3 and activation of eRK 66 days post infection (dpi). By 180 dpi there was a normalization of these values. these data suggest that the reduction in Cav-3 expression and the activation of ERK during the early phase of infection may contribute to the pathogenesis of chagasic cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)1639-1646
Number of pages8
JournalCell Cycle
Volume9
Issue number8
DOIs
StatePublished - Apr 15 2010

Keywords

  • Cardiac myocytes
  • Caveolae
  • Caveolin-3
  • ERK
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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