Trypanosoma cruzi infection

A review with emphasis on cutaneous manifestations

Vagish S. Hemmige, Herbert Tanowitz, Aisha Sethi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Chagas disease, an infection caused by the protozoan Trypanosoma cruzi and transmitted by the Reduuvid insect vector, remains a major cause of morbidity in Central and South America over a century after its discovery in 1909. Though major advances in preventing the spread of this disease have been made in recent decades, millions of individuals remain chronically infected due to prior exposure to T. cruzi and are at risk for future complications from the disease. Dermatologic manifestations of acute infection may include localized swelling at the site of inoculation (chagoma), conjunctivitis (Romaña's sign), and a generalized morbilliform eruption (schizotrypanides). Reactivation of quiescent infection in immunocompromised hosts due to the acquired immunodeficiency syndrome or organ transplantation can present with fever and skin lesions including panniculitis. The widespread emigration of chronic carriers of T. cruzi to North America, Europe, and Australia makes it imperative that dermatologists worldwide be familiar with this entity to ensure proper diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)501-508
Number of pages8
JournalInternational Journal of Dermatology
Volume51
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Skin Manifestations
Trypanosoma cruzi
Infection
Protozoan Infections
Insect Vectors
Panniculitis
Central America
Conjunctivitis
Chagas Disease
South America
Emigration and Immigration
Immunocompromised Host
Organ Transplantation
North America
Acquired Immunodeficiency Syndrome
Fever
Morbidity
Skin
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Trypanosoma cruzi infection : A review with emphasis on cutaneous manifestations. / Hemmige, Vagish S.; Tanowitz, Herbert; Sethi, Aisha.

In: International Journal of Dermatology, Vol. 51, No. 5, 05.2012, p. 501-508.

Research output: Contribution to journalArticle

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