Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Patamaporn Pruksakorn, Masayoshi Arai, Naoyuki Kotoku, Catherine Vilchze, Anthony D. Baughn, Prashini Moodley, William R. Jacobs, Motomasa Kobayashi

Research output: Contribution to journalArticle

96 Scopus citations


Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.

Original languageEnglish (US)
Pages (from-to)3658-3663
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number12
StatePublished - May 18 2010



  • Aminolipopeptide
  • Anti-mycobacterial activity
  • Dormant
  • Trichoderin
  • Trichoderma sp.
  • Tuberculosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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