Treatment of obsessive-compulsive spectrum disorders with SSRIs

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Background: Obsessive-compulsive spectrum disorders (OCSDs) are now recognised as distinct diagnostic entities related to obsessive-compulsive disorder (OCD). The features of OCSDs and OCD overlap in many respects including demographics, repetitive intrusive thoughts or behaviours, comorbidity, aetiology and preferential response to anti-obsessional drugs such as the selective serotonin reuptake inhibitors (SSRIs). Method: Literature was reviewed and preliminary data from various studies were re- examined to assess the relationship between compulsivity and impulsivity, and between OCD and OCSDs. Results: OCSDs include both compulsive and impulsive disorders and these can be viewed as lying at opposite ends of the dimension of risk avoidance. Compulsiveness is associated with increased frontal lobe activity and increased serotonergic activity, while impulsiveness is associated with reduced activity of these variables. Neural circuits affected by serotonergic pathways have been identified and pharmacological challenge of OCSD patients with serotonin receptor agonists have supported the involvement of serotonergic processes. Conclusions: SSRIs such as fluvoxamine have established efficacy in OCD and preliminary studies indicate that they are also effective in OCSDs. The features of three specimen OCSDs body dysmorphic disorder, pathological gambling and autism - and their treatment with SSRIs are reviewed.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalBritish Journal of Psychiatry
Volume173
Issue numberSUPPL. 35
StatePublished - 1998
Externally publishedYes

Fingerprint

Obsessive-Compulsive Disorder
Serotonin Uptake Inhibitors
Therapeutics
Body Dysmorphic Disorders
Fluvoxamine
Serotonin Receptor Agonists
Gambling
Impulsive Behavior
Frontal Lobe
Autistic Disorder
Comorbidity
Demography
Pharmacology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Treatment of obsessive-compulsive spectrum disorders with SSRIs. / Hollander, Eric.

In: British Journal of Psychiatry, Vol. 173, No. SUPPL. 35, 1998, p. 7-12.

Research output: Contribution to journalArticle

@article{9c995ef8bd444f73939b74da3d9da9d1,
title = "Treatment of obsessive-compulsive spectrum disorders with SSRIs",
abstract = "Background: Obsessive-compulsive spectrum disorders (OCSDs) are now recognised as distinct diagnostic entities related to obsessive-compulsive disorder (OCD). The features of OCSDs and OCD overlap in many respects including demographics, repetitive intrusive thoughts or behaviours, comorbidity, aetiology and preferential response to anti-obsessional drugs such as the selective serotonin reuptake inhibitors (SSRIs). Method: Literature was reviewed and preliminary data from various studies were re- examined to assess the relationship between compulsivity and impulsivity, and between OCD and OCSDs. Results: OCSDs include both compulsive and impulsive disorders and these can be viewed as lying at opposite ends of the dimension of risk avoidance. Compulsiveness is associated with increased frontal lobe activity and increased serotonergic activity, while impulsiveness is associated with reduced activity of these variables. Neural circuits affected by serotonergic pathways have been identified and pharmacological challenge of OCSD patients with serotonin receptor agonists have supported the involvement of serotonergic processes. Conclusions: SSRIs such as fluvoxamine have established efficacy in OCD and preliminary studies indicate that they are also effective in OCSDs. The features of three specimen OCSDs body dysmorphic disorder, pathological gambling and autism - and their treatment with SSRIs are reviewed.",
author = "Eric Hollander",
year = "1998",
language = "English (US)",
volume = "173",
pages = "7--12",
journal = "The British journal of psychiatry : the journal of mental science",
issn = "0007-1250",
publisher = "Royal College of Psychiatrists",
number = "SUPPL. 35",

}

TY - JOUR

T1 - Treatment of obsessive-compulsive spectrum disorders with SSRIs

AU - Hollander, Eric

PY - 1998

Y1 - 1998

N2 - Background: Obsessive-compulsive spectrum disorders (OCSDs) are now recognised as distinct diagnostic entities related to obsessive-compulsive disorder (OCD). The features of OCSDs and OCD overlap in many respects including demographics, repetitive intrusive thoughts or behaviours, comorbidity, aetiology and preferential response to anti-obsessional drugs such as the selective serotonin reuptake inhibitors (SSRIs). Method: Literature was reviewed and preliminary data from various studies were re- examined to assess the relationship between compulsivity and impulsivity, and between OCD and OCSDs. Results: OCSDs include both compulsive and impulsive disorders and these can be viewed as lying at opposite ends of the dimension of risk avoidance. Compulsiveness is associated with increased frontal lobe activity and increased serotonergic activity, while impulsiveness is associated with reduced activity of these variables. Neural circuits affected by serotonergic pathways have been identified and pharmacological challenge of OCSD patients with serotonin receptor agonists have supported the involvement of serotonergic processes. Conclusions: SSRIs such as fluvoxamine have established efficacy in OCD and preliminary studies indicate that they are also effective in OCSDs. The features of three specimen OCSDs body dysmorphic disorder, pathological gambling and autism - and their treatment with SSRIs are reviewed.

AB - Background: Obsessive-compulsive spectrum disorders (OCSDs) are now recognised as distinct diagnostic entities related to obsessive-compulsive disorder (OCD). The features of OCSDs and OCD overlap in many respects including demographics, repetitive intrusive thoughts or behaviours, comorbidity, aetiology and preferential response to anti-obsessional drugs such as the selective serotonin reuptake inhibitors (SSRIs). Method: Literature was reviewed and preliminary data from various studies were re- examined to assess the relationship between compulsivity and impulsivity, and between OCD and OCSDs. Results: OCSDs include both compulsive and impulsive disorders and these can be viewed as lying at opposite ends of the dimension of risk avoidance. Compulsiveness is associated with increased frontal lobe activity and increased serotonergic activity, while impulsiveness is associated with reduced activity of these variables. Neural circuits affected by serotonergic pathways have been identified and pharmacological challenge of OCSD patients with serotonin receptor agonists have supported the involvement of serotonergic processes. Conclusions: SSRIs such as fluvoxamine have established efficacy in OCD and preliminary studies indicate that they are also effective in OCSDs. The features of three specimen OCSDs body dysmorphic disorder, pathological gambling and autism - and their treatment with SSRIs are reviewed.

UR - http://www.scopus.com/inward/record.url?scp=0031847453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031847453&partnerID=8YFLogxK

M3 - Article

C2 - 9829021

AN - SCOPUS:0031847453

VL - 173

SP - 7

EP - 12

JO - The British journal of psychiatry : the journal of mental science

JF - The British journal of psychiatry : the journal of mental science

SN - 0007-1250

IS - SUPPL. 35

ER -