Treatment of locally advanced esophageal carcinoma: ASCO guideline

Manish A. Shah, Erin B. Kennedy, Daniel V. Catenacci, Dana C. Deighton, Karyn A. Goodman, Narinder K. Malhotra, Christopher Willett, Brendon Stiles, Prateek Sharma, Laura Tang, Bas P.L. Wijnhoven, Wayne L. Hofstetter

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

PURPOSE To develop an evidence-based clinical practice guideline to assist in clinical decision making for patients with locally advanced esophageal cancer. METHODS ASCO convened an Expert Panel to conduct a systematic review of the more recently published literature (1999-2019) on therapy options for patients with locally advanced esophageal cancer and provide recommended care options for this patient population. RESULTS Seventeen randomized controlled trials met the inclusion criteria. Where possible, data were extracted separately for squamous cell carcinoma and adenocarcinoma. RECOMMENDATIONS Multimodality therapy for patients with locally advanced esophageal carcinoma is recommended. For the subgroup of patients with adenocarcinoma, preoperative chemoradiotherapy or perioperative chemotherapy should be offered. For the subgroup of patients with squamous cell carcinoma, preoperative chemoradiotherapy or chemoradiotherapy without surgery should be offered. Additional subgroup considerations are provided to assist with implementation of these recommendations. Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines.

Original languageEnglish (US)
Pages (from-to)2677-2694
Number of pages18
JournalJournal of Clinical Oncology
Volume38
Issue number23
DOIs
StatePublished - Aug 2020
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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