Treatment of high-grade squamous intraepithelial Lesion

A 2- verus 3-step approach

Lillian Berdichevsky, Randye Karmin, Linus Chuang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: The purpose of this study was to determine whether colposcopically directed biopsy is a necessary step in the evaluation of patients with high-grade squamous intraepithelial lesions. Study design: A retrospective analysis was conducted of the correlation between the high-grade squamous intraepithelial lesion Papanicolaou test and the colposcopically directed biopsy and the correlation between the high-grade squamous intraepithelial lesion Papanicolaou test and the loop electrosurgical excisional procedure. Results: Of 72 patients with high-grade squamous intraepithelial lesions on Papanicolaou test, 48 patients had a pathologic diagnosis on cervical biopsy of CIN II or greater, which provides a 67% correlation between the Papanicolaou test and the colposcopically directed biopsy. Fifty-six patients had a pathologic diagnosis on loop electrosurgical excisional procedure of CIN II or greater, which provides a 78% correlation between the Papanicolaou test and the loop electrosurgical excisional procedure. The median interval between the Papanicolaou test and the definitive treatment was significantly longer (P < .001) when colposcopically directed biopsy was performed before the loop electrosurgical excisional procedure. Conclusion: The colposcopically directed loop electrosurgical excisional procedure after a high-grade squamous intraepithelial lesion Papanicolaou test may reduce the time interval between diagnosis and treatment; furthermore, it offers equal correlation when compared with traditional treatment.

Original languageEnglish (US)
Pages (from-to)1424-1426
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume190
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

Fingerprint

Papanicolaou Test
varespladib methyl
Biopsy
Therapeutics
Squamous Intraepithelial Lesions of the Cervix

Keywords

  • High-grade squamous intraepithelial lesion
  • Loop electrosurgical excisional procedure

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Treatment of high-grade squamous intraepithelial Lesion : A 2- verus 3-step approach. / Berdichevsky, Lillian; Karmin, Randye; Chuang, Linus.

In: American Journal of Obstetrics and Gynecology, Vol. 190, No. 5, 05.2004, p. 1424-1426.

Research output: Contribution to journalArticle

Berdichevsky, Lillian ; Karmin, Randye ; Chuang, Linus. / Treatment of high-grade squamous intraepithelial Lesion : A 2- verus 3-step approach. In: American Journal of Obstetrics and Gynecology. 2004 ; Vol. 190, No. 5. pp. 1424-1426.
@article{e79596709f084a17b9c9812fde03f7ff,
title = "Treatment of high-grade squamous intraepithelial Lesion: A 2- verus 3-step approach",
abstract = "Objective: The purpose of this study was to determine whether colposcopically directed biopsy is a necessary step in the evaluation of patients with high-grade squamous intraepithelial lesions. Study design: A retrospective analysis was conducted of the correlation between the high-grade squamous intraepithelial lesion Papanicolaou test and the colposcopically directed biopsy and the correlation between the high-grade squamous intraepithelial lesion Papanicolaou test and the loop electrosurgical excisional procedure. Results: Of 72 patients with high-grade squamous intraepithelial lesions on Papanicolaou test, 48 patients had a pathologic diagnosis on cervical biopsy of CIN II or greater, which provides a 67{\%} correlation between the Papanicolaou test and the colposcopically directed biopsy. Fifty-six patients had a pathologic diagnosis on loop electrosurgical excisional procedure of CIN II or greater, which provides a 78{\%} correlation between the Papanicolaou test and the loop electrosurgical excisional procedure. The median interval between the Papanicolaou test and the definitive treatment was significantly longer (P < .001) when colposcopically directed biopsy was performed before the loop electrosurgical excisional procedure. Conclusion: The colposcopically directed loop electrosurgical excisional procedure after a high-grade squamous intraepithelial lesion Papanicolaou test may reduce the time interval between diagnosis and treatment; furthermore, it offers equal correlation when compared with traditional treatment.",
keywords = "High-grade squamous intraepithelial lesion, Loop electrosurgical excisional procedure",
author = "Lillian Berdichevsky and Randye Karmin and Linus Chuang",
year = "2004",
month = "5",
doi = "10.1016/j.ajog.2004.01.073",
language = "English (US)",
volume = "190",
pages = "1424--1426",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Treatment of high-grade squamous intraepithelial Lesion

T2 - A 2- verus 3-step approach

AU - Berdichevsky, Lillian

AU - Karmin, Randye

AU - Chuang, Linus

PY - 2004/5

Y1 - 2004/5

N2 - Objective: The purpose of this study was to determine whether colposcopically directed biopsy is a necessary step in the evaluation of patients with high-grade squamous intraepithelial lesions. Study design: A retrospective analysis was conducted of the correlation between the high-grade squamous intraepithelial lesion Papanicolaou test and the colposcopically directed biopsy and the correlation between the high-grade squamous intraepithelial lesion Papanicolaou test and the loop electrosurgical excisional procedure. Results: Of 72 patients with high-grade squamous intraepithelial lesions on Papanicolaou test, 48 patients had a pathologic diagnosis on cervical biopsy of CIN II or greater, which provides a 67% correlation between the Papanicolaou test and the colposcopically directed biopsy. Fifty-six patients had a pathologic diagnosis on loop electrosurgical excisional procedure of CIN II or greater, which provides a 78% correlation between the Papanicolaou test and the loop electrosurgical excisional procedure. The median interval between the Papanicolaou test and the definitive treatment was significantly longer (P < .001) when colposcopically directed biopsy was performed before the loop electrosurgical excisional procedure. Conclusion: The colposcopically directed loop electrosurgical excisional procedure after a high-grade squamous intraepithelial lesion Papanicolaou test may reduce the time interval between diagnosis and treatment; furthermore, it offers equal correlation when compared with traditional treatment.

AB - Objective: The purpose of this study was to determine whether colposcopically directed biopsy is a necessary step in the evaluation of patients with high-grade squamous intraepithelial lesions. Study design: A retrospective analysis was conducted of the correlation between the high-grade squamous intraepithelial lesion Papanicolaou test and the colposcopically directed biopsy and the correlation between the high-grade squamous intraepithelial lesion Papanicolaou test and the loop electrosurgical excisional procedure. Results: Of 72 patients with high-grade squamous intraepithelial lesions on Papanicolaou test, 48 patients had a pathologic diagnosis on cervical biopsy of CIN II or greater, which provides a 67% correlation between the Papanicolaou test and the colposcopically directed biopsy. Fifty-six patients had a pathologic diagnosis on loop electrosurgical excisional procedure of CIN II or greater, which provides a 78% correlation between the Papanicolaou test and the loop electrosurgical excisional procedure. The median interval between the Papanicolaou test and the definitive treatment was significantly longer (P < .001) when colposcopically directed biopsy was performed before the loop electrosurgical excisional procedure. Conclusion: The colposcopically directed loop electrosurgical excisional procedure after a high-grade squamous intraepithelial lesion Papanicolaou test may reduce the time interval between diagnosis and treatment; furthermore, it offers equal correlation when compared with traditional treatment.

KW - High-grade squamous intraepithelial lesion

KW - Loop electrosurgical excisional procedure

UR - http://www.scopus.com/inward/record.url?scp=2542449855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542449855&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2004.01.073

DO - 10.1016/j.ajog.2004.01.073

M3 - Article

VL - 190

SP - 1424

EP - 1426

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 5

ER -