TY - JOUR
T1 - Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice
AU - Jiang, Zewei
AU - Bryan, Ruth A.
AU - Morgenstern, Alfred
AU - Bruchertseifer, Frank
AU - Casadevall, Arturo
AU - Dadachova, Ekaterina
PY - 2012/1
Y1 - 2012/1
N2 - We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent mice. RIT with 213Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while 188Re-18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic.
AB - We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent mice. RIT with 213Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while 188Re-18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic.
UR - http://www.scopus.com/inward/record.url?scp=84455161653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84455161653&partnerID=8YFLogxK
U2 - 10.1128/AAC.00473-11
DO - 10.1128/AAC.00473-11
M3 - Article
C2 - 22005995
AN - SCOPUS:84455161653
SN - 0066-4804
VL - 56
SP - 552
EP - 554
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 1
ER -
