Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice

Zewei Jiang, Ruth A. Bryan, Alfred Morgenstern, Frank Bruchertseifer, Arturo Casadevall, Ekaterina Dadachova

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent mice. RIT with 213Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while 188Re-18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic.

Original languageEnglish (US)
Pages (from-to)552-554
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number1
DOIs
StatePublished - Jan 2012

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Radioimmunotherapy
Cryptococcus neoformans
Lung
Antibodies
Infection
Brain
Fungi
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice. / Jiang, Zewei; Bryan, Ruth A.; Morgenstern, Alfred; Bruchertseifer, Frank; Casadevall, Arturo; Dadachova, Ekaterina.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 1, 01.2012, p. 552-554.

Research output: Contribution to journalArticle

Jiang, Zewei ; Bryan, Ruth A. ; Morgenstern, Alfred ; Bruchertseifer, Frank ; Casadevall, Arturo ; Dadachova, Ekaterina. / Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice. In: Antimicrobial Agents and Chemotherapy. 2012 ; Vol. 56, No. 1. pp. 552-554.
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