Treatment of chronic, refractory cough with baclofen

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Chronic, nonproductive cough may result from enhanced sensitivity of the cough reflex. Often, this debilitating symptom is refractory to standard antitussive therapy. Baclofen, an agonist of γ-aminobutyric acid (GABA), has been shown, in animals, to have antitussive activity via a central mechanism. Recently, in normal subjects, we have demonstrated the ability of baclofen to inhibit capsaicin-induced cough, as well as cough due to angiotensin-converting enzyme (ACE) inhibitors. Herein, we describe two patients with chronic, refractory cough who obtained symptomatic improvement after a 14-day course of low-dose, oral baclofen, administered in a double-blind, placebo-controlled manner. In addition, both subjects demonstrated significant increases in cough threshold to inhaled capsaicin after treatment with baclofen.

Original languageEnglish (US)
Pages (from-to)86-88
Number of pages3
JournalRespiration
Volume65
Issue number1
DOIs
StatePublished - Jan 1998

Fingerprint

Baclofen
Cough
Antitussive Agents
Capsaicin
Therapeutics
Aminobutyrates
Aptitude
Angiotensin-Converting Enzyme Inhibitors
gamma-Aminobutyric Acid
Reflex
Placebos

Keywords

  • Baclofen
  • Capsaicin
  • Cough
  • GABA

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Treatment of chronic, refractory cough with baclofen. / Dicpinigaitis, Peter Vytautas; Rauf, Khalid.

In: Respiration, Vol. 65, No. 1, 01.1998, p. 86-88.

Research output: Contribution to journalArticle

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