Abstract
Chronic, nonproductive cough may result from enhanced sensitivity of the cough reflex. Often, this debilitating symptom is refractory to standard antitussive therapy. Baclofen, an agonist of γ-aminobutyric acid (GABA), has been shown, in animals, to have antitussive activity via a central mechanism. Recently, in normal subjects, we have demonstrated the ability of baclofen to inhibit capsaicin-induced cough, as well as cough due to angiotensin-converting enzyme (ACE) inhibitors. Herein, we describe two patients with chronic, refractory cough who obtained symptomatic improvement after a 14-day course of low-dose, oral baclofen, administered in a double-blind, placebo-controlled manner. In addition, both subjects demonstrated significant increases in cough threshold to inhaled capsaicin after treatment with baclofen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 86-88 |
| Number of pages | 3 |
| Journal | Respiration |
| Volume | 65 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1998 |
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Keywords
- Baclofen
- Capsaicin
- Cough
- GABA
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Physiology
Cite this
Treatment of chronic, refractory cough with baclofen. / Dicpinigaitis, Peter Vytautas; Rauf, Khalid.
In: Respiration, Vol. 65, No. 1, 01.1998, p. 86-88.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of chronic, refractory cough with baclofen
AU - Dicpinigaitis, Peter Vytautas
AU - Rauf, Khalid
PY - 1998/1
Y1 - 1998/1
N2 - Chronic, nonproductive cough may result from enhanced sensitivity of the cough reflex. Often, this debilitating symptom is refractory to standard antitussive therapy. Baclofen, an agonist of γ-aminobutyric acid (GABA), has been shown, in animals, to have antitussive activity via a central mechanism. Recently, in normal subjects, we have demonstrated the ability of baclofen to inhibit capsaicin-induced cough, as well as cough due to angiotensin-converting enzyme (ACE) inhibitors. Herein, we describe two patients with chronic, refractory cough who obtained symptomatic improvement after a 14-day course of low-dose, oral baclofen, administered in a double-blind, placebo-controlled manner. In addition, both subjects demonstrated significant increases in cough threshold to inhaled capsaicin after treatment with baclofen.
AB - Chronic, nonproductive cough may result from enhanced sensitivity of the cough reflex. Often, this debilitating symptom is refractory to standard antitussive therapy. Baclofen, an agonist of γ-aminobutyric acid (GABA), has been shown, in animals, to have antitussive activity via a central mechanism. Recently, in normal subjects, we have demonstrated the ability of baclofen to inhibit capsaicin-induced cough, as well as cough due to angiotensin-converting enzyme (ACE) inhibitors. Herein, we describe two patients with chronic, refractory cough who obtained symptomatic improvement after a 14-day course of low-dose, oral baclofen, administered in a double-blind, placebo-controlled manner. In addition, both subjects demonstrated significant increases in cough threshold to inhaled capsaicin after treatment with baclofen.
KW - Baclofen
KW - Capsaicin
KW - Cough
KW - GABA
UR - http://www.scopus.com/inward/record.url?scp=0031908998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031908998&partnerID=8YFLogxK
U2 - 10.1159/000029232
DO - 10.1159/000029232
M3 - Article
C2 - 9523374
AN - SCOPUS:0031908998
VL - 65
SP - 86
EP - 88
JO - Respiration; international review of thoracic diseases
JF - Respiration; international review of thoracic diseases
SN - 0025-7931
IS - 1
ER -