Abstract
Objective To compare the behavioral improvement to find the best transplantation approach for treating brain injury through transplanting amniotic-derived mesenchymal stem cells into brain injured rats in different ways. Methods Eighty brain injured Wista rats were randomly divided into a control group with brain injury alone (n = 20) and a treatment group (n = 60) which were further evenly divided into Group A ( transplanted through the vena caudalis ) , Group B (transplanted through the ventriculus cerebri lateralis) , and Group C (transplanted through the injured brain area) . Each group was transplanted with amniotic - derived esenchymal stem cells , and their therapeutic efficacy would be evaluated through the neurological severity score (NSS) Results Compared with other groups, the behaviors of Group C had markedly improved. There was statistically significant difference in the 2 groups (P<0.05). Compared with the control group, the behaviors of Group A and Group B had marked improvement. There was statistically significant difference in the 3 groups (P<0.05). However, there was no significant difference between Group A and the control group (P>0.05) . Conclusion Transplanting the amniotic - derived mesenchymal stem cells into the injured brain area may be effective for brain injury in rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 926-930 |
| Number of pages | 5 |
| Journal | Journal of Central South University (Medical Sciences) |
| Volume | 33 |
| Issue number | 10 |
| State | Published - Oct 2008 |
| Externally published | Yes |
Keywords
- Amniotic-derived mesenchymal
- Brain injury
- Rats
- Stem cell
- Transplantation
ASJC Scopus subject areas
- General Medicine