Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways

Gong Ping Wang, Bo Yang, Fang Xia Guan, Ying Du, Ke Liang Chang, Lai Jun Song, Xiang Hu, Guang Wei Zeng

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective To compare the behavioral improvement to find the best transplantation approach for treating brain injury through transplanting amniotic-derived mesenchymal stem cells into brain injured rats in different ways. Methods Eighty brain injured Wista rats were randomly divided into a control group with brain injury alone (n = 20) and a treatment group (n = 60) which were further evenly divided into Group A ( transplanted through the vena caudalis ) , Group B (transplanted through the ventriculus cerebri lateralis) , and Group C (transplanted through the injured brain area) . Each group was transplanted with amniotic - derived esenchymal stem cells , and their therapeutic efficacy would be evaluated through the neurological severity score (NSS) Results Compared with other groups, the behaviors of Group C had markedly improved. There was statistically significant difference in the 2 groups (P<0.05). Compared with the control group, the behaviors of Group A and Group B had marked improvement. There was statistically significant difference in the 3 groups (P<0.05). However, there was no significant difference between Group A and the control group (P>0.05) . Conclusion Transplanting the amniotic - derived mesenchymal stem cells into the injured brain area may be effective for brain injury in rats.

Original languageEnglish (US)
Pages (from-to)926-930
Number of pages5
JournalJournal of Central South University (Medical Sciences)
Volume33
Issue number10
StatePublished - Oct 1 2008

    Fingerprint

Keywords

  • Amniotic-derived mesenchymal
  • Brain injury
  • Rats
  • Stem cell
  • Transplantation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wang, G. P., Yang, B., Guan, F. X., Du, Y., Chang, K. L., Song, L. J., Hu, X., & Zeng, G. W. (2008). Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways. Journal of Central South University (Medical Sciences), 33(10), 926-930.