Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways

Gong Ping Wang, Bo Yang, Fangxia Guan, Ying Du, Ke Liang Chang, Lai Jun Song, Xiang Hu, Guang Wei Zeng

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective To compare the behavioral improvement to find the best transplantation approach for treating brain injury through transplanting amniotic-derived mesenchymal stem cells into brain injured rats in different ways. Methods Eighty brain injured Wista rats were randomly divided into a control group with brain injury alone (n = 20) and a treatment group (n = 60) which were further evenly divided into Group A ( transplanted through the vena caudalis ) , Group B (transplanted through the ventriculus cerebri lateralis) , and Group C (transplanted through the injured brain area) . Each group was transplanted with amniotic - derived esenchymal stem cells , and their therapeutic efficacy would be evaluated through the neurological severity score (NSS) Results Compared with other groups, the behaviors of Group C had markedly improved. There was statistically significant difference in the 2 groups (P<0.05). Compared with the control group, the behaviors of Group A and Group B had marked improvement. There was statistically significant difference in the 3 groups (P<0.05). However, there was no significant difference between Group A and the control group (P>0.05) . Conclusion Transplanting the amniotic - derived mesenchymal stem cells into the injured brain area may be effective for brain injury in rats.

Original languageEnglish (US)
Pages (from-to)926-930
Number of pages5
JournalJournal of Central South University (Medical Sciences)
Volume33
Issue number10
StatePublished - Oct 2008
Externally publishedYes

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Mesenchymal Stromal Cells
Brain Injuries
Brain
Stem Cells
Transplantation
Control Groups
Therapeutics

Keywords

  • Amniotic-derived mesenchymal
  • Brain injury
  • Rats
  • Stem cell
  • Transplantation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways. / Wang, Gong Ping; Yang, Bo; Guan, Fangxia; Du, Ying; Chang, Ke Liang; Song, Lai Jun; Hu, Xiang; Zeng, Guang Wei.

In: Journal of Central South University (Medical Sciences), Vol. 33, No. 10, 10.2008, p. 926-930.

Research output: Contribution to journalArticle

Wang, Gong Ping ; Yang, Bo ; Guan, Fangxia ; Du, Ying ; Chang, Ke Liang ; Song, Lai Jun ; Hu, Xiang ; Zeng, Guang Wei. / Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways. In: Journal of Central South University (Medical Sciences). 2008 ; Vol. 33, No. 10. pp. 926-930.
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