Treating uncomplicated malaria in children: Comparing artemisinin-based combination therapies

Adoke Yeka, Jamal C. Harris

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Purpose of Review: In response to increased resistance to conventional drugs, the WHO is promoting artemisinin-based combination therapy (ACT) for treating uncomplicated malaria. The objective of this report is to review the available evidence on the efficacy and effectiveness, acceptability, and deployment of ACT in resource-limited settings with a focus on sub-Saharan Africa. Recent Findings: ACTs are very effective in the treatment of uncomplicated Plasmodium falciparum malaria in children. ACTs are relatively safe and tolerable with no reported resistance in sub-Saharan Africa despite indications of delayed clearance of infections in south-east Asia. The major challenges to the widespread use of ACT include its high cost, availability, and inefficient delivery due to, among other things, weak healthcare systems. Summary: ACTs are an essential tool in the fight to control and eliminate malaria. They are currently the most effective drugs against P. falciparum malaria. They should be deployed through programs that address availability, cost, adherence, and quality assurance. Initiatives including home-based management of malaria, improving public sector procurement and supply chains, and reducing private sector pricing should make ACTs more accessible for sub-Saharan African children who bear the brunt of the burden of malarial disease.

Original languageEnglish (US)
Pages (from-to)798-803
Number of pages6
JournalCurrent Opinion in Pediatrics
Issue number6
StatePublished - Dec 2010
Externally publishedYes


  • artemisinin-based combination therapy
  • home-based malaria management
  • malaria
  • malaria diagnostics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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