Transport and biological impact of manganese

Keith M. Erikson, Khristy J. Thompson, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Manganese (Mn) is an essential nutrient and, unlike other trace elements (e.g., iron), toxicity is more prevalent than dietary deficiency. This chapter will commence with a discussion on the essentiality of Mn and its general biological functions. We will then discuss putative Mn transport mechanisms with a particular emphasis on the lung and brain, the primary organs involved in the etiology of Mn neurotoxicity (manganism). We conclude the chapter with several sections focusing on the neurobiology of manganism. Special emphasis is placed on the neurochemical and biochemical aspects of Mn-induced neuropathology and the biochemical similarities it shares with Parkinson’s disease (PD).

Original languageEnglish (US)
Title of host publicationCellular and Molecular Biology of Metals
PublisherCRC Press
Pages127-142
Number of pages16
ISBN (Electronic)9781420059984
ISBN (Print)9781420059977
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Biological Transport
Manganese
Neurobiology
Trace Elements
Nutrients
Parkinson Disease
Toxicity
Brain
Iron
Food
Lung

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Erikson, K. M., Thompson, K. J., & Aschner, M. (2010). Transport and biological impact of manganese. In Cellular and Molecular Biology of Metals (pp. 127-142). CRC Press. https://doi.org/10.1201/9781420059984

Transport and biological impact of manganese. / Erikson, Keith M.; Thompson, Khristy J.; Aschner, Michael.

Cellular and Molecular Biology of Metals. CRC Press, 2010. p. 127-142.

Research output: Chapter in Book/Report/Conference proceedingChapter

Erikson, KM, Thompson, KJ & Aschner, M 2010, Transport and biological impact of manganese. in Cellular and Molecular Biology of Metals. CRC Press, pp. 127-142. https://doi.org/10.1201/9781420059984
Erikson KM, Thompson KJ, Aschner M. Transport and biological impact of manganese. In Cellular and Molecular Biology of Metals. CRC Press. 2010. p. 127-142 https://doi.org/10.1201/9781420059984
Erikson, Keith M. ; Thompson, Khristy J. ; Aschner, Michael. / Transport and biological impact of manganese. Cellular and Molecular Biology of Metals. CRC Press, 2010. pp. 127-142
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