Transport and biological impact of manganese

Keith M. Erikson, Khristy J. Thompson, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Manganese (Mn) is an essential nutrient and, unlike other trace elements (e.g., iron), toxicity is more prevalent than dietary deficiency. This chapter will commence with a discussion on the essentiality of Mn and its general biological functions. We will then discuss putative Mn transport mechanisms with a particular emphasis on the lung and brain, the primary organs involved in the etiology of Mn neurotoxicity (manganism). We conclude the chapter with several sections focusing on the neurobiology of manganism. Special emphasis is placed on the neurochemical and biochemical aspects of Mn-induced neuropathology and the biochemical similarities it shares with Parkinson’s disease (PD).

Original languageEnglish (US)
Title of host publicationCellular and Molecular Biology of Metals
PublisherCRC Press
Pages127-142
Number of pages16
ISBN (Electronic)9781420059984
ISBN (Print)9781420059977
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Erikson, K. M., Thompson, K. J., & Aschner, M. (2010). Transport and biological impact of manganese. In Cellular and Molecular Biology of Metals (pp. 127-142). CRC Press. https://doi.org/10.1201/9781420059984