Transplacental transmission of Cryptococcus neoformans to an HIV-exposed premature neonate

M. Patel, K. P. Beckerman, S. Reznik, R. P. Madan, David L. Goldman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cryptococcosis during pregnancy is well documented, but transmission of infection to the fetus is rare. We describe a premature neonate born to a mother with congenitally acquired human immunodeficiency virus (HIV) and active cryptococcosis. Histological examination of the placenta revealed Cryptococcus neoformans within the maternal intervillous space with focal invasion into the chorionic villi. A positive serum cryptococcal antigen (1:2) was detected on days 1 and 5 of life. The neonate had no evidence of central nervous system disease and was treated with fluconazole with resolution of antigenemia. This case highlights both the potential for transplacental transmission of C. neoformans infection and the complexities of caring for pregnant mothers who themselves are congenitally infected with HIV.

Original languageEnglish (US)
Pages (from-to)235-237
Number of pages3
JournalJournal of Perinatology
Volume32
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Cryptococcosis
Cryptococcus neoformans
HIV
Chorionic Villi
Infectious Disease Transmission
Fluconazole
Central Nervous System Diseases
Placenta
Fetus
Mothers
Antigens
Pregnancy
Infection
Serum

Keywords

  • congenital HIV
  • cryptococcus
  • neonate
  • placenta
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Transplacental transmission of Cryptococcus neoformans to an HIV-exposed premature neonate. / Patel, M.; Beckerman, K. P.; Reznik, S.; Madan, R. P.; Goldman, David L.

In: Journal of Perinatology, Vol. 32, No. 3, 03.2012, p. 235-237.

Research output: Contribution to journalArticle

Patel, M. ; Beckerman, K. P. ; Reznik, S. ; Madan, R. P. ; Goldman, David L. / Transplacental transmission of Cryptococcus neoformans to an HIV-exposed premature neonate. In: Journal of Perinatology. 2012 ; Vol. 32, No. 3. pp. 235-237.
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