Translocation t(12;19)(q13;q13.3). A new recurrent abnormality in acute nonlymphocytic leukemia with atypical erythropoiesis

Elisabeth M. Paietta, Peter Papenhausen, Rasim A. Gucalp, Peter H. Wiernik

Research output: Contribution to journalArticle

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Abstract

A new reciprocal, apparently balanced translocation between chromosomes 12 and 19, t(12;19)(q13;q13.3), was detected in 5% ( 3 59) of patients with FAB M1 or M2 acute nonlymphocytic leukemia. In either case, this translocation was part of complex but different cytogenetic abnormalities. None of the patients had a significant response to therapy. In one instance, however, the translocation was found at first relapse after 2 years of complete remission, and no information regarding the karyotype at disease onset was available. Hematologically common to these patients were marked marrow erythroid hyperplasia and severely abnormal erythropoiesis despite normal serum B12 and folate levels. A direct association between t(12;19) and these hematologic findings will have to be established as more cases with this chromosomal abnormality are identified.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume34
Issue number1
DOIs
StatePublished - 1988

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Erythropoiesis
Acute Myeloid Leukemia
Chromosome Aberrations
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 12
Karyotype
Folic Acid
Hyperplasia
Bone Marrow
Recurrence
Serum
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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Translocation t(12;19)(q13;q13.3). A new recurrent abnormality in acute nonlymphocytic leukemia with atypical erythropoiesis. / Paietta, Elisabeth M.; Papenhausen, Peter; Gucalp, Rasim A.; Wiernik, Peter H.

In: Cancer Genetics and Cytogenetics, Vol. 34, No. 1, 1988, p. 19-23.

Research output: Contribution to journalArticle

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