Transition state analysis of thymidine hydrolysis by human thymidine phosphorylase

Medicine & Life Sciences

• Thymidine Phosphorylase 100%
• Thymidine 67%
• Hydrolysis 63%
• Deoxyribose 54%
• Thymine 46%
• Water 45%
• Density Functional Theory 29%
• Phosphates 29%
• Ribose 23%
• Histidine 19%
• Isotopes 18%
• Carbon 16%
• Catalytic Domain 15%
• Homeostasis 12%
• Kinetics 12%
• Glucose 10%

Engineering & Materials Science

• Hydrolysis 82%
• Nucleophiles 71%
• Phosphates 39%
• Water 37%
• Chemical activation 30%
• Density functional theory 25%
• Conformations 21%
• Isotopes 21%
• Glucose 19%
• Molecules 16%
• Carbon 12%

Chemical Compounds

• Thymidine 75%
• Transition State 56%
• Hydrolysis 42%
• Thymine 24%
• Nucleophile 19%
• Phosphate 15%
• Transition State Structure 14%
• Ribose 13%
• Kinetic Isotope Effect 12%
• Histidine 10%
• Glucose 8%
• Density Functional Theory 7%
• Energy 5%
• Carbon Atom 5%
• Molecule 3%