Transition-state analysis for depurination of DNA by ricin A-chain

Medicine & Life Sciences

• Ricin 100%
• Isotopes 76%
• Kinetics 51%
• DNA 39%
• Ions 17%
• RNA 14%
• Density Functional Theory 12%
• Ribonucleotides 10%
• Peptide Elongation Factors 9%
• Ribosomal RNA 9%
• Catalysis 8%
• Adenine 8%
• DNA-Directed DNA Polymerase 7%
• Oligonucleotides 7%
• Hydrolysis 6%
• Nucleotides 5%

Engineering & Materials Science

• Isotopes 86%
• DNA 73%
• RNA 25%
• Ions 19%
• Conformations 17%
• Ribosomal RNA 12%
• Stabilization 11%
• Oligonucleotides 10%
• Density functional theory 10%
• Cytotoxicity 10%
• Catalysis 9%
• Nucleotides 8%
• Geometry 8%
• Hydrolysis 8%
• Elongation 6%
• Substrates 4%

Chemical Compounds

• Ricin 97%
• Kinetic Isotope Effect 77%
• Transition State 58%
• Toxin 13%
• dATP 10%
• Ribosomal RNA 9%
• Hyperconjugation 9%
• Ribonucleotide 8%
• Ion 8%
• Adenine 6%
• Oligonucleotide 6%
• Nucleotide 5%
• Catalysis 4%
• Density Functional Theory 4%
• Hydrolysis 4%