Transgenic assays for mutations and cancer: Current status and future perspectives

Jan Vijg, Harry Van Steeg

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Transgenic mouse modelling has proved to be a powerful approach to explore the various steps involved in spontaneous and induced carcinogenesis. Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. Here, we review the progress in the development and use of transgenic mouse models specifically for the purpose of carcinogenicity and mutagenicity testing.

Original languageEnglish (US)
Pages (from-to)337-354
Number of pages18
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume400
Issue number1-2
DOIs
StatePublished - May 25 1998
Externally publishedYes

Keywords

  • Carcinogenicity
  • DNA repair gene
  • LacZ reporter gene
  • Mutagenicity
  • Risk estimation
  • Transgenic mouse model
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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