Transgenic assays for mutations and cancer: Current status and future perspectives

Jan Vijg; Harry Van Steeg

doi:10.1016/S0027-5107(98)00030-X

Transgenic assays for mutations and cancer: Current status and future perspectives

Jan Vijg, Harry Van Steeg

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Transgenic mouse modelling has proved to be a powerful approach to explore the various steps involved in spontaneous and induced carcinogenesis. Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. Here, we review the progress in the development and use of transgenic mouse models specifically for the purpose of carcinogenicity and mutagenicity testing.

Original language	English (US)
Pages (from-to)	337-354
Number of pages	18
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	400
Issue number	1-2
DOIs	https://doi.org/10.1016/S0027-5107(98)00030-X
State	Published - May 25 1998
Externally published	Yes

Keywords

Carcinogenicity
DNA repair gene
LacZ reporter gene
Mutagenicity
Risk estimation
Transgenic mouse model
Tumor suppressor gene

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0027-5107(98)00030-X

Cite this

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title = "Transgenic assays for mutations and cancer: Current status and future perspectives",

abstract = "Transgenic mouse modelling has proved to be a powerful approach to explore the various steps involved in spontaneous and induced carcinogenesis. Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. Here, we review the progress in the development and use of transgenic mouse models specifically for the purpose of carcinogenicity and mutagenicity testing.",

keywords = "Carcinogenicity, DNA repair gene, LacZ reporter gene, Mutagenicity, Risk estimation, Transgenic mouse model, Tumor suppressor gene",

author = "Jan Vijg and {Van Steeg}, Harry",

note = "Funding Information: We thank Drs. P.H.M. Lohman and C.F. van Kreijl for critically reading the manuscript. This work was supported by NIH grants PO1 AG10829, P30 AG13314 and 1 RO1 CA75653-02, the European Communities Biotechnology Programme, BIO-CT92-0004-NL and the Dutch Cancer Society, RIVM95-1064.",

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doi = "10.1016/S0027-5107(98)00030-X",

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T1 - Transgenic assays for mutations and cancer

T2 - Current status and future perspectives

AU - Vijg, Jan

AU - Van Steeg, Harry

N1 - Funding Information: We thank Drs. P.H.M. Lohman and C.F. van Kreijl for critically reading the manuscript. This work was supported by NIH grants PO1 AG10829, P30 AG13314 and 1 RO1 CA75653-02, the European Communities Biotechnology Programme, BIO-CT92-0004-NL and the Dutch Cancer Society, RIVM95-1064.

PY - 1998/5/25

Y1 - 1998/5/25

N2 - Transgenic mouse modelling has proved to be a powerful approach to explore the various steps involved in spontaneous and induced carcinogenesis. Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. Here, we review the progress in the development and use of transgenic mouse models specifically for the purpose of carcinogenicity and mutagenicity testing.

AB - Transgenic mouse modelling has proved to be a powerful approach to explore the various steps involved in spontaneous and induced carcinogenesis. Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. Here, we review the progress in the development and use of transgenic mouse models specifically for the purpose of carcinogenicity and mutagenicity testing.

KW - Carcinogenicity

KW - DNA repair gene

KW - LacZ reporter gene

KW - Mutagenicity

KW - Risk estimation

KW - Transgenic mouse model

KW - Tumor suppressor gene

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Transgenic assays for mutations and cancer: Current status and future perspectives

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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