Abstract
Mercury is a hazardous substance that has unique neurodevelopmental toxic effects in humans. However, the precise sequence of molecular events that culminate in Hg-induced neuropathology is still unknown. Though the omics studies have been generating an enormous amount of new data about Hg toxicity, our ability to interpret such a large quantity of information is still limited. In this opinion article, we will reinforce the necessity of new high throughput and accurate analytical proteomic methodologies, especially, thiol and selenol-proteome. Overall, we posit that improvements in thiol- and selenol-proteomic analyses will be pivotal in identifying the primary cellular targets of Hg. However, a better understanding of the complex cascades and molecular pathways involved in its toxicity will require extensive complementary studies in more complex systems.
Original language | English (US) |
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Article number | 425 |
Journal | Frontiers in Genetics |
Volume | 11 |
DOIs | |
State | Published - May 5 2020 |
Keywords
- methylmercury
- neurotoxicity
- proteome
- selenol
- thiol
- transcriptome
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Genetics(clinical)