Transcriptomic and Proteomic Tools in the Study of Hg Toxicity: What Is Missing?

Cláudia S. Oliveira, Ana L.A. Segatto, Pablo A. Nogara, Bruna C. Piccoli, Élgion L.S. Loreto, Michael Aschner, João B.T. Rocha

Research output: Contribution to journalReview article

Abstract

Mercury is a hazardous substance that has unique neurodevelopmental toxic effects in humans. However, the precise sequence of molecular events that culminate in Hg-induced neuropathology is still unknown. Though the omics studies have been generating an enormous amount of new data about Hg toxicity, our ability to interpret such a large quantity of information is still limited. In this opinion article, we will reinforce the necessity of new high throughput and accurate analytical proteomic methodologies, especially, thiol and selenol-proteome. Overall, we posit that improvements in thiol- and selenol-proteomic analyses will be pivotal in identifying the primary cellular targets of Hg. However, a better understanding of the complex cascades and molecular pathways involved in its toxicity will require extensive complementary studies in more complex systems.

Original languageEnglish (US)
Article number425
JournalFrontiers in Genetics
Volume11
DOIs
StatePublished - May 5 2020

Keywords

  • methylmercury
  • neurotoxicity
  • proteome
  • selenol
  • thiol
  • transcriptome

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

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  • Cite this

    Oliveira, C. S., Segatto, A. L. A., Nogara, P. A., Piccoli, B. C., Loreto, É. L. S., Aschner, M., & Rocha, J. B. T. (2020). Transcriptomic and Proteomic Tools in the Study of Hg Toxicity: What Is Missing? Frontiers in Genetics, 11, [425]. https://doi.org/10.3389/fgene.2020.00425