Transcriptional regulation of T cell tolerance

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Self-reactive T cells that escape negative selection in the thymus must be kept under control in the periphery. Mechanisms of peripheral tolerance include deletion or functional inactivation of self-reactive T cells and mechanisms of dominant tolerance mediated by regulatory T cells. In the absence of costimulation, T cell receptor (TCR) engagement results in unopposed calcium signaling that leads to the activation of a cell-intrinsic program of inactivation, which makes T cells hyporesponsive to subsequent stimulations. The activation of this program in anergic T cells is a consequence of the induction of a nuclear factor of activated T cells (NFAT)-dependent program of gene expression. Recent studies have offered new insights into the mechanisms responsible for the implementation and maintenance of T cell anergy and have provided evidence that the proteins encoded by the genes upregulated in anergic T cells are responsible for the implementation of anergy by interfering with TCR signaling or directly inhibiting cytokine gene transcription.

Original languageEnglish (US)
Pages (from-to)180-187
Number of pages8
JournalSeminars in Immunology
Volume19
Issue number3
DOIs
StatePublished - Jun 2007

Keywords

  • Anergy
  • Calcium
  • Egr
  • Ikaros
  • NFAT
  • T cell
  • Transcription

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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